PREDICT Data Model

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Schema IDhttps://models.d4cg.org/predict

Releasepredict-20270101

LicenseCC BY-NC 4.0

Concepts11 classes · 88 slots · 49 enums

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Demographics

Demographics contains subject identity, demographic characteristics, survival status, family and medical history, and longitudinal timing information needed to interpret records across the model.

SubjectCharacteristics `1..1`

Core identifying and administrative characteristics for each subject in the data model.

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
data_contributor_id		`ncit:C168950`	An identifier assigned to a data contributor.
data_source		`ncit:C16493`	Source of information collected in the course of a clinical trial, specifically used to differentiate between data as collected versus data that are derived or calculated. NOTE: In CDISC, a metadata attribute defined for each dataset variable in the Define.xml document of an SDTM submission that refers to the source of a variable (e.g., CRF, derived, sponsor defined, PRO, etc.). See also data element originator.
last_known_survival_status
age_last_contact	`decimal`
age_last_contact_unit
age_last_contact_precision

Slot Icons:Required

Timing `0..*`

Timing information used to associate observations and events with a subject and timepoint.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
timepoint
timing_age_at	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.

Slot Icons:Required

FamilyMedicalHistory `0..*`

Family medical history information for conditions reported among a subject's relatives.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
relation_honest_broker_subject_id	`string`
relation		`ncit:C21480`	A person related by blood or marriage.
condition
syndromic_condition
source

Slot Icons:Required

Demographics `1..1`

Demographic characteristics of each subject, including sex, race, and ethnicity.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
sex		`ncit:C28421`	An arbitrary categorization of individuals based on the assemblage of physical properties related to reproduction, and commonly associated with the designation of such categories as female and male. This designation is based on a combination of observable information from organ inventories, morphological assessments, hormone assessments, genetic testing, observed primary and secondary sex characteristics, menstrual status, and/or obstetric history. Current sex designation may or may not be the same as an individual's sex assigned or reported at birth. IMPORTANT NOTICE: The NCI Thesaurus contains biomedical terminologies that NCI does not own or control. This concept contains gender-related content that does not comply with Executive Order 14168.
ethnicity		`ncit:C16564`	A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease.
race		`ncit:C17049`	A geographic ancestral origin category that is assigned to a population group based mainly on physical characteristics that are thought to be distinct and inherent.

Slot Icons:Required

MedicalHistory `0..*`

Medical history conditions reported for a subject.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
medical_history_condition		`ncit:C18772`	A collection of information about a person's health. It may include information about allergies, illnesses and surgeries, and dates and results of physical exams, tests, screenings, and immunizations. It may also include information about medicines taken and about diet and exercise.
condition_other	`string`	`ncit:C53263`	Relevant elements of medical history, including preexisting medical conditions, events and facts (e.g., allergies, race, pregnancy, smoking and alcohol use, hepatic/renal dysfunction, etc.) not listed in MedWatch form.
condition_code	`string`
code_system

Slot Icons:Required

Testing

Testing contains biometric, biospecimen, laboratory, and genetic observations used to characterize subjects and support diagnosis and longitudinal evaluation.

Biometrics `0..*`

Biometric measurements collected for a subject, including measurement values and associated timing.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
measurement_type
measurement_numeric	`decimal`
measurement_unit
z_score	`decimal`

Slot Icons:Required

Biospecimen `0..*`

Biospecimens collected from a subject and their specimen types.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
sample_type

Slot Icons:Required

GeneticAnalysis `0..*`

Genetic and genomic analysis results for a subject, including genes, alterations, methods, and reported significance.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
causative_alteration
status
genetic_analysis_sample_type
laboratory_name
cytogenetic_location	`string`
method
gene		`ncit:C173595`	The gene symbol that represents either a single gene that has a mutation or the gene that comprises the 5' portion of the coding sequence involved in a fusion gene mutation.
alteration_type
alteration_effect		`ncit:C204195`	The effect of a sequence change on the function of an RNA, DNA, or protein.
alteration_region
hgvs_accession	`string`
hgvs_coding	`string`	`ncit:C198546`	The designation of a DNA coding sequence variation based on the Human Genome Variation Society (HGVS) nomenclature guidelines.
hgvs_protein	`string`	`ncit:C97928`	A variation in the sequence of a specific gene product.
hgvs_genomic	`string`
iscn	`string`	`ncit:C156450`	An international standard for human chromosome nomenclature, which includes band names, symbols and abbreviated terms used in the description of human chromosome and chromosome abnormalities.
reported_significance
allelic_state
maf_numeric	`decimal`	`ncit:C173545`	The determination of the ratio of variant alleles to wild-type alleles present in a sample.
mosaicism		`ncit:C92976`	The occurrence of 2 or more cell lines with different genetic or chromosomal make-up, within a single individual or tissue.
external_ref_id	`string`
external_ref_id_system

Slot Icons:Required

Testing `0..*`

Clinical laboratory and diagnostic test results collected for a subject.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
test_type
testing_method
testing_measurement_type
result_modifier	`string`
result_numeric	`string`	`ncit:C185629`	The result of a function test expressed as a number.
result_unit
reference_range	`string`
result_interpretation
fasting_status
post_glucose_timepoint	`string`
post_glucose_timepoint_unit

Slot Icons:Required

Disease Attributes

Disease Attributes contains clinical characteristics related to diabetes, glycemic status, hypoglycemia, diabetic ketoacidosis, glucose monitoring, diet, exercise, and other features used to characterize disease status over time.

DiseaseCharacteristics `0..*`

Clinical characteristics and observations related to a subject's diabetes and glycemic status.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
diabetes_status
hypoglycemia_frequency
severe_hypoglycemia_frequency
dka
time_in_range	`decimal`
cgm_range
cgm_context
diet
exercise

Slot Icons:Required

Intervention

Intervention contains medication and treatment records, including medication class, drug, dose, route, frequency, treatment timing, and reasons for treatment discontinuation.

Treatment `0..*`

Medication and treatment information for a subject, including dose, route, frequency, and treatment timing.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at_start	`decimal`
age_at_stop	`decimal`
age_unit
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
reason_stop
dm_medication_class
medication_class_other
medication_name	`string`
medication_code	`string`
medication_concentration
medication_dose	`decimal`
medication_unit
frequency
route		`ncit:C186559`	The intended area to be affected by the choice of a particular route of administration of a medication.

Permissible Value	Meaning	Description
Approximate	`ncit:C45828`	Not quite exact or correct; almost exact or correct.
Exact	`ncit:C86021`	Marked by strict and particular and complete accordance with fact.

Permissible Value	Meaning	Description
Years
Months
Weeks
Days

Permissible Value	Meaning	Description
Homozygous	`ncit:C45826`	Having two identical allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
Heterozygous	`ncit:C45825`	Having two different allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
Compound Heterozygous	`ncit:C198518`	Having two different allelic forms of a gene, one inherited from each parent, where each allele harbors a different genetic variation or gene mutation.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Frameshift	`ncit:C17354`	A mutation occurring within the protein-coding region of a gene which results in a shift in the reading frame of the encoded protein. Frameshift mutations often result in the premature truncation of a gene product.
Missense	`ncit:C18133`	A point mutation occurring within the protein-coding region of a gene, and which codes for a different amino acid than expected.
Stop Gained (Nonsense)
None (Inframe)

Permissible Value	Meaning	Description
Splice Site	`ncit:C45574`	An inherited single base substitution in a sequence of eukaryotic DNA located in either an acceptor (3' or downstream) or donor (5' or upstream) splice site of a gene. Functional single nucleotide polymorphisms in these intron-exon junctions can cause incorrect RNA splicing which, in turn, alters gene expression.
5' UTR	`ncit:C13371`	Sequences on the 5' end of messenger RNAs that are not translated into protein. 5'UTR extends from the transcription start site to just before the ATG translation initiation codon. This region contains the ribosome binding site and other transcription and translation regulating sequences.
3' UTR	`ncit:C13373`	Sequences on the 3' end of messenger RNAs that are not translated into protein. The 3'UTR is involved in many post-transcriptional regulatory pathways, including regulating translation efficiency, mRNA stability, and polyadenylation signals.

Permissible Value	Meaning	Description
Chromosome Arm Gain
Chromosome Arm Loss
Substitution
Deletion	`ncit:C16606`	A deletion that results in the loss of a DNA segment encompassing an entire gene sequence.
Insertion	`so:0000667`	The sequence of one or more nucleotides added between two adjacent nucleotides in the sequence.
Indel
Duplication
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Most Recent
Change In Treatment
Other	`ncit:C17649`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
CTCAE	`ncit:C49704`	A standard terminology developed and maintained by the National Cancer Institute to report adverse events occurring in cancer clinical trials. The CTCAE contains a grading scale for each adverse event term representing the severity of the event. (NCI)
ICD-9
ICD-10
SNOMED-CT

Permissible Value	Meaning	Description
Prediabetes
Type 1 Diabetes
Type 2 Diabetes
Monogenic Diabetes
Gestational Diabetes
Diabetes, NOS

Permissible Value	Meaning	Description
Yes - Hyperglycemic DKA
Yes - Euglycemic DKA
No	`ncit:C49487`	The non-affirmative response to a question.
Unknown	`ncit:C17998`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
Insulin, Rapid-Acting
Insulin, Long-Acting
Insulin, Intermediate-Acting
Insulin, Combination
Insulin, NOS
Biguanide
Sulfonylurea
Meglitinide
Thiazolidinedione
Dipeptidylpeptidase 4 Inhibitor
Sodium-Glucose Co-Transporter 2 Inhibitor
GLP-1 Receptor Agonist
Dual GLP-1/GIP Receptor Agonist
Amylin Analog
Alpha-Glucosidase Inhibitor
Bile Acid-Binding Resin

Permissible Value	Meaning	Description
UChicago Monogenic Diabetes Research Group
Barbara Davis Center / UColorado
Baylor
Boston Children's
Cincinnati Children's Hospital
Endeavor
Indiana
MGH
Maryland
Michigan
Nebraska
NorthShore
WashU

Permissible Value	Meaning	Description
Yes	`ncit:C49488`	The affirmative response to a question.
No	`ncit:C49487`	The non-affirmative response to a question.

Permissible Value	Meaning	Description
Hispanic or Latino	`ncit:C17459`	A person of Mexican, Puerto Rican, Cuban, Central or South American or other Spanish culture or origin, regardless of race. (NCI)
Not Hispanic or Latino	`ncit:C41222`	A person not of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Fasting
Non-Fasting
Random	`ncit:C60702`	Governed by or depending on chance; lacking any definite plan or order or purpose.

Permissible Value	Meaning	Description
Once per day
Once per day, Morning
Once per day, Evening
Two times a day
Three times a day
Four times a day
As needed
Before every meal
Before meals and at bedtime
Every week

Permissible Value	Meaning	Description
6q24-Related Abnormalities
ABCC8
CEL
CFTR
DCAF17
EIF2AK3
FOXP3
GATA4
GATA6
GCK
GLIS3
HNF1A
HNF1B
HNF4A
IAPP (Amylin)
IER3IP1
IGF2/Russell Silver Syndrome
IL2RA
INS
INSR
KCNJ11
LRBA
mtDNA
NEUROD1
PAX4
PCBD1
PDX1 (IPF1)
PTF1A
RFX6
STAT3
WFS1
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Saliva	`ncit:C174119`	A small volume of saliva removed for testing or storage.
Blood	`ncit:C17610`	A small volume of blood removed for testing or storage.
Buccal
Urine	`ncit:C13283`	Fluid containing water and waste products. Urine is made by the kidneys, stored in the bladder, and leaves the body through the urethra.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Once or twice in past year
Every few months
Once or twice a month
Once or twice a week
Daily or every other day
Never	`ncit:C70543`	Not ever; at no time (in the past or future).
Unknown	`ncit:C17998`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
Ambry Genetics
Athena
Baylor Genetics
Blueprint
Exeter
GeneDx
Invitae
LMG
Research Lab
Seattle Children's Hospital
UCGSL
Prevention Genetics
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Alive	`ncit:C37987`	Living; showing characteristics of life.
Dead
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Height/Length
Weight	`ncit:C81328`	A measurement that describes the vertical force exerted by a mass of the patient as a result of gravity.
BMI	`ncit:C138901`	The result of a body mass index measurement.
Raw BMI

Permissible Value	Meaning	Description
kg	`ncit:C28252`	A basic SI unit of mass. It is defined as the mass of an international prototype in the form of a platinum-iridium cylinder kept at Sevres in France. A kilogram is equal to 1,000 grams and 2.2046226 pounds.
cm	`ncit:C49668`	A basic unit of length equal to one hundredth of a meter or approximately 0.393700787 inch.
kg/m^2
percentile

Permissible Value	Meaning	Description
Abnormal Kidney Shape, Size, Or Number
Absent Or Missing Pancreas
Behavioral Difficulties
Congenital Heart Defect
Coronary Artery Disease
Difficulty With Social Interactions
Elevated Liver Enzymes / LFTs
Fatty Liver
Genitourinary Developmental Malformation Or Abnormality
Gestational Diabetes
Hepatomegaly
High Cholesterol, NOS
High Frequency Hearing Loss
High LDL
High Total Cholesterol
High Triglycerides
Hypertension	`ncit:C3117`	A blood pressure of 140/90 or higher. High blood pressure usually has no symptoms. It can harm the arteries and cause an increase in the risk of stroke, heart attack, kidney failure, and blindness.
Hypoglycemia In Infancy
Intrauterine Growth Restriction	`ncit:C87088`	A fetus whose estimated weight is below the 10th percentile for its gestational age; however, many fetuses who meet this definition are simply small-for-gestational-age and are constitutionally small. The diagnosis of intrauterine growth restriction carries an increased risk of perinatal morbidity and mortality.
Liver Adenoma
Low Frequency Hearing Loss
Low HDL
Macroglossia
Nephropathy
Peripheral Artery Disease
Peripheral Neuropathy
Polycystic Kidney Disease
Proteinuria	`ncit:C38012`	A disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.
Renal Cyst
Retinopathy	`ncit:C55891`	A disorder involving the retina.
Small For Gestational Age	`ncit:C114934`	A newborn infant who has weight and/or length at birth more than two standard deviations below the mean for the reference population of the same sex and gestational age.
Small Pancreas
Stroke
Umbilical Hernia
Other	`ncit:C17649`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
ACE Inhibitor
ACL Inhibitor
Angiotensin II Receptor Blockers
ANGPTL3 Inhibitor
Antiepileptic
Antilipemic siRNA
Beta Blocker
Calcium Channel Blocker
Cholesterol Absorption Inhibitor
Coenzyme Q
Diuretic
Fibrates
Finerenone
Glucagon
Magnesium
Mineralcorticoid Receptor
Pancreatic Enzymes
PCSK9 Inhibitor
Psychoactive
Statin

Permissible Value	Meaning	Description
U100
U200
U300
U500
Not Applicable	`ncit:C48660`	A report has been received but the description provided does not appear to relate to an adverse event. This code allows a report to be recorded for administration purposes, even if it doesn't meet the requirements for adverse event reporting.

Permissible Value	Meaning	Description
Units
mg	`ncit:C28253`	A measure of weight. A milligram is approximately 450,000 times smaller than a pound and 28,000 times smaller than an ounce.
mcg	`ncit:C48152`	A metric unit of mass equal to one millionth of a gram or one thousandth of a milligram.
gm
ml
tbsp
tsp
IU	`ncit:C48579`	A unit used to measure the activity of many vitamins, hormones, enzymes, and drugs. An IU is the amount of a substance that has a certain biological effect. For each substance there is an international agreement on the biological effect that is expected for 1 IU.
puffs
Packets
mg/ml
application

Permissible Value	Meaning	Description
Karyotyping
Fluorescence In Situ Hybridization
RT-PCR
PCR	`ncit:C17003`	A laboratory method used to make many copies of a specific DNA sequence.
MLPA
Sequencing, Sanger, Capillary Electropheresis
Sequencing, Sanger, Gel Electropheresis
Sequencing, Sanger, NOS
Sequencing, NGS, Whole Genome	`ncit:C101294`	A DNA sequencing technique in which the entirety of the individual's genome is sequenced.
Sequencing, NGS, lcWGS
Sequencing, NGS, Whole Exome	`ncit:C101295`	A DNA sequencing technique in which all of the exons of an individual's genome are sequenced.
Sequencing, NGS, Multi-Gene Panel
Sequencing, NGS, Single Site
Sequencing, NGS, Single Gene DNA
Sequencing, NGS, Targeted DNA
Sequencing, NGS, Targeted RNA
Sequencing, NGS, Total RNA
Sequencing, NGS, TDS
Sequencing, NGS, NOS	`ncit:C101293`	A type of sequencing technology that makes use of high-throughput parallel sequencing of multiple fragments of DNA or RNA.
Sequencing, Methylation Array
Sequencing, Nanostring
SNP Array
Array CGH
Genotyping, NOS	`ncit:C45447`	The determination of the DNA sequence of an individual.
Cytogenetics, NOS	`ncit:C16487`	The branch of biology that studies the cellular aspects of heredity, especially the chromosomes. Includes the study of disease states caused by numerical and structural chromosome abnormalities.
Other	`ncit:C17649`	A proper value is applicable but not known.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
American Indian or Alaska Native	`ncit:C41259`	A person having origins in any of the original peoples of North and South America (including Central America), and who maintains tribal affiliation or community attachment. (FDA)
Asian	`ncit:C41260`	A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent including, for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam. (FDA)
Black or African American	`ncit:C16352`	A person having origins in any of the black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American." (FDA)
Native Hawaiian or Other Pacific Islander	`ncit:C41219`	Denotes a person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. The term covers particularly people who identify themselves as part-Hawaiian, Native Hawaiian, Guamanian or Chamorro, Carolinian, Samoan, Chuu. (FDA)
White	`ncit:C41261`	Denotes a person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White. (FDA)
Multiracial	`ncit:C67109`	Having ancestors of several or various races.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

PREDICT Data Model

SubjectCharacteristics 1..1

Timing 0..*

FamilyMedicalHistory 0..*

Demographics 1..1

MedicalHistory 0..*

Biometrics 0..*

Biospecimen 0..*

GeneticAnalysis 0..*

Testing 0..*

DiseaseCharacteristics 0..*

Treatment 0..*

AgeLastContactPrecisionEnum

AgeLastContactUnitEnum

AllelicStateEnum

AlterationEffectEnum

AlterationRegionEnum

AlterationTypeEnum

CGMContextEnum

CGMRangeEnum

CodeSystemEnum

ConditionEnum

DKAEnum

DMMedicationClassEnum

DataContributorIDEnum

DataSourceEnum

DiabetesStatusEnum

EthnicityEnum

ExternalRefIDSystemEnum

FastingStatusEnum

FrequencyEnum

GeneEnum

GeneticAnalysisSampleTypeEnum

HypoglycemiaFrequencyEnum

LaboratoryNameEnum

LastKnownSurvivalStatusEnum

MeasurementTypeEnum

MeasurementUnitEnum

MedicalHistoryConditionEnum

MedicationClassOtherEnum

MedicationConcentrationEnum

MedicationUnitEnum

MethodEnum

PostGlucoseTimepointUnitEnum

RaceEnum

ReasonStopEnum

RelationEnum

ReportedSignificanceEnum

ResultInterpretationEnum

ResultUnitEnum

RouteEnum

SampleTypeEnum

SexEnum

SourceEnum

StatusEnum

SyndromicConditionEnum

TestTypeEnum

TestingMeasurementTypeEnum

TestingMethodEnum

TimepointEnum

YesNoEnum

Table of contents

SubjectCharacteristics `1..1`

Timing `0..*`

FamilyMedicalHistory `0..*`

Demographics `1..1`

MedicalHistory `0..*`

Biometrics `0..*`

Biospecimen `0..*`

GeneticAnalysis `0..*`

Testing `0..*`

DiseaseCharacteristics `0..*`

Treatment `0..*`

Permissible Value	Meaning	Description
Planned Stop
No Significant Effect
Side Effects
Not Insured
Cost
Unknown	`ncit:C17998`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
Father	`ncit:C96572`	A male who contributes to the genetic makeup of his offspring through the fertilization of an ovum by his sperm.
Mother	`ncit:C96580`	A female who contributes to the genetic makeup of her offspring from the fertilization of her ovum.
Son	`ncit:C150888`	A male progeny with genetic makeup inherited from the parent.
Daughter	`ncit:C150887`	A female progeny with genetic makeup inherited from the parent.
Brother	`ncit:C96570`	A male who shares with his sibling the genetic makeup inherited from one or both of their shared biological parents.
Sister
Spouse/Partner
Grandfather (Paternal)
Grandfather (Maternal)
Grandfather (Paternal/Maternal Unknown)
Grandmother (Paternal)
Grandmother (Maternal)
Grandmother (Paternal/Maternal Unknown)
Uncle (Paternal)
Uncle (Maternal)
Uncle (Paternal/Maternal Unknown)
Aunt (Paternal)
Aunt (Maternal)
Aunt (Paternal/Maternal Unknown)
Niece
Nephew
First Cousin (Paternal)
First Cousin (Maternal)
First Cousin (Paternal/Maternal Unknown)
Great-Grandfather (Paternal)
Great-Grandfather (Maternal)
Great-Grandfather (Paternal/Maternal Unknown)
Great-Grandmother (Paternal)
Great-Grandmother (Maternal)
Great-Grandmother (Paternal/Maternal Unknown)
Great-Uncle (Paternal)
Great-Uncle (Maternal)
Great-Uncle (Paternal/Maternal Unknown)
Great-Aunt (Paternal)
Great-Aunt (Maternal)
Great-Aunt (Paternal/Maternal Unknown)
Other	`ncit:C17649`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
Pathogenic	`ncit:C168799`	A genetic variant that is known to directly contribute to the development of disease.
Likely Pathogenic	`ncit:C168800`	A genetic variant that is known to have a high likelihood (greater than 90% certainty) to contribute to the development of a disease.
Pathogenic/Likely Pathogenic
Likely Pathogenic/Uncertain Significance
Uncertain Significance	`ncit:C94187`	A variation in a genetic sequence whose association with disease risk is unknown.
Likely Benign	`ncit:C168801`	A genetic variant that is not expected to contribute to the development of a disease, but the scientific evidence may be insufficient to prove this conclusively.
Uncertain Significance/Likely Benign
Benign
Likely Benign/Benign
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Positive
Negative	`ncit:C38757`	A finding of normality following an examination or investigation looking for the presence of a microorganism, disease, or condition.

Permissible Value	Meaning	Description
%	`ncit:C48570`	A unit for expressing a number as a fraction of hundred (on the basis of a rate or proportion per hundred).
mg/dL	`ncit:C67015`	A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters.
U/L	`ncit:C67456`	A unit of substance concentration equal to the concentration at which one liter of mixture contains one unit of a substance.
U/mL	`ncit:C77607`	A unit of substance content expressed in unit(s) per milliliter.
mmol/L	`ncit:C64387`	A unit of concentration (molarity unit) equal to one millimole of solute per liter of solution.
ng/mL	`ncit:C67306`	A unit of concentration or mass density equal to one nanogram of substance per milliliter of solution or one microgram of substance per liter of solution.
nmol/L
mg/g
mg/L	`ncit:C64572`	A metric unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one cubic meter. The concept also refers to the metric unit of mass density (volumic mass) defined as the density of a substance which mass equal to one gram occupies the volume of one cubic meter.
IU/mL

Permissible Value	Meaning	Description
Male	`ncit:C20197`	A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. [The NCI Thesaurus contains biomedical terminologies that NCI does not own or control. This concept contains gender-related content that does not comply with Executive Order 14168.]
Female	`ncit:C16576`	A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both. [The NCI Thesaurus contains biomedical terminologies that NCI does not own or control. This concept contains gender-related content that does not comply with Executive Order 14168.]
Undifferentiated	`ncit:C41438`	Sex could not be determined; not uniquely defined; undifferentiated.

Permissible Value	Meaning	Description
Present	`ncit:C25566`	Pertaining to or characterized by metaplasia.
Absent	`ncit:C25567`	Refers to a tumor that has spread to anatomic sites away from the original site of growth or has reappeared in any anatomic site. The vast majority of such tumors are malignant.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported

Permissible Value	Meaning	Description
Hypoglycemia
Genitourinary Developmental Malformation Or Abnormality
Abnormal Kidney Shape, Size, Or Number
Kidney Cysts
Hypomagnesemia
Encephalomyopathy
Lactic Acidosis
Stroke-Like Episodes
Hearing Loss
Optic Atrophy

Permissible Value	Meaning	Description
HbA1c
C-Peptide
Blood Glucose
Autoantibodies, GAD65
Autoantibodies, ZnT8
Autoantibodies, IA-2
Autoantibodies, Insulin
Autoantibodies, Islet Cell
Autoantibodies, NOS	`ncit:C181397`	A measurement of the binding autoantibody in a biological specimen.
Total Cholesterol	`ncit:C61032`	A quantitative measurement of the total amount of cholesterol present in a sample of serum.
Triglycerides
HDL
LDL	`ncit:C189506`	A measurement of the low density lipoprotein triglyceride in a biological specimen.
Serum Magnesium
Serum Potassium
Serum Creatinine
Serum BUN
GFR
Urine Microalbumin
Urine Creatinine
Microalbumin/Creatinine Ratio
Urine Magnesium
ALT	`ncit:C64433`	A measurement of the alanine aminotransferase in a biological specimen.
AST	`ncit:C64467`	A measurement of the aspartate aminotransferase in a biological specimen.

Permissible Value	Meaning	Description
Average High
14-day Average
30-day Average
90-day Average
Average
Average Low
Point