PCDC Data Model

Schema IDhttps://models.d4cg.org/pcdc

Releasepcdc-20270101

LicenseCC BY-NC 4.0

Concepts40 classes · 754 slots · 377 enums

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Scope Matrix

Domain	Class	ALL	AML	CNS	EWS	FA	FPRH	GCT	HL	LS	LT	NBL	NPC	NRSTS	OS	PRE	RB	RMS
Demographics	ClinicalEpisode
Demographics	Consult
Demographics	ExternalReference
Demographics	FamilyMedicalHistory
Demographics	MedicalHistory
Demographics	OffProtocolTherapyOrStudy
Demographics	ProviderCharacteristics
Demographics	SocialAndBehavioralDeterminantsOfHealth
Demographics	StudyMetadata
Demographics	StudySubgroupAssignment
Demographics	Subject
Demographics	SurvivalCharacteristics
Disease Attributes	Diagnosis
Disease Attributes	DiseaseCharacteristics
Disease Attributes	DiseaseSiteAssessment
Disease Attributes	Staging
Intervention	CellularImmunotherapy
Intervention	FertilityProcedures
Intervention	LocoregionalTherapy
Intervention	Medication
Intervention	ProtocolTreatmentModifications
Intervention	RadiationTherapy
Intervention	StemCellTransplant
Intervention	SurgicalProcedures
Intervention	TransfusionMedicineProcedure
Monitoring	AdverseEvents
Monitoring	LateEffects
Monitoring	MinimalResidualDisease
Monitoring	PatientReportedOutcomesMetadata
Monitoring	ReproductiveAndPubertalStatus
Monitoring	ReproductiveOutcomes
Monitoring	SubjectResponse
Monitoring	SubsequentMalignantNeoplasm
Testing	Biospecimen
Testing	FunctionTest
Testing	GeneticAnalysis
Testing	Immunohistochemistry
Testing	LaboratoryTest
Testing	VitalsAndAnthropometrics

Rendered Raw

Demographics

Demographics contains subject identity, enrollment, study participation, longitudinal episode structure, survival status, family and medical history, and other contextual information needed to interpret records across the model.

Subject `1..1`

Subject represents an enrolled or contributed study participant and captures core identifiers, contributor context, disease group membership, demographic attributes, ancestry-related fields, and selected follow-up status fields.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
data_contributor_id		`ncit:C168950`	An identifier assigned to a data contributor.
study_id		`ncit:C83082`	A sequence of characters used to identify, name, or characterize the study.
consortium		`ncit:C61538`	A group formed to undertake a venture that is beyond the capabilities of the individual members. Each member of the consortium brings a high level of expertise in a specific area to ensure the successful completion of the project.
disease_group
sex		`ncit:C28421`	An arbitrary categorization of individuals based on the assemblage of physical properties related to reproduction, and commonly associated with the designation of such categories as female and male. This designation is based on a combination of observable information from organ inventories, morphological assessments, hormone assessments, genetic testing, observed primary and secondary sex characteristics, menstrual status, and/or obstetric history. Current sex designation may or may not be the same as an individual's sex assigned or reported at birth. IMPORTANT NOTICE: The NCI Thesaurus contains biomedical terminologies that NCI does not own or control. This concept contains gender-related content that does not comply with Executive Order 14168.
race		`ncit:C17049`	A geographic ancestral origin category that is assigned to a population group based mainly on physical characteristics that are thought to be distinct and inherent.
race_identification_source
race_other	`string`
race_specified
ethnicity		`ncit:C16564`	A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease.
ethnicity_other	`string`
ethnicity_specified
country	`string`
ashkenazi_jewish_ancestry
efs_censor_status
age_at_censor_status	`integer`
enrolled_status		`ncit:C168928`	The current status of the subject's enrollment.
age_at_enrollment	`integer`	`ncit:C168843`	Age of subject (in days) when the subject enrolled in the study.
year_at_enrollment	`integer`	`ncit:C177353`	The year at which a subject enrolled in a study.

Slot Icons:Required

ExternalReference `0..*`

ExternalReference captures links between a PCDC subject and identifiers or URLs in external resources, enabling cross-resource navigation and provenance for linked data assets.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
external_links	`string`
external_resource_icon_path	`string`
external_resource_id	`string`
external_resource_name	`string`
external_subject_id	`string`
external_subject_submitter_id	`string`
external_subject_url	`string`

Slot Icons:Required

StudyMetadata `1..1`

StudyMetadata describes the study, registry, trial, institutional database, or other data source context in which a subject or cohort was enrolled or represented.

Slot	Range	Slot URI	Description
study_id		`ncit:C83082`	A sequence of characters used to identify, name, or characterize the study.
study_age_precision
data_source		`ncit:C16493`	Source of information collected in the course of a clinical trial, specifically used to differentiate between data as collected versus data that are derived or calculated. NOTE: In CDISC, a metadata attribute defined for each dataset variable in the Define.xml document of an SDTM submission that refers to the source of a variable (e.g., CRF, derived, sponsor defined, PRO, etc.). See also data element originator.
study_phase		`ncit:C48281`	A stage in the clinical research and development of a therapy from first-in-human to post-approval clinical trials.
study_type		`ncit:C142175`	The nature of the investigation for which study information is being collected. (After clinicaltrials.gov)
urls	`string`

Slot Icons:Required

StudySubgroupAssignment `0..*`

StudySubgroupAssignment captures a subject's assignment to study strata, treatment arms, risk groups, or other protocol-defined subgroups, including ordering and randomization context where applicable.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
study_id		`ncit:C83082`	A sequence of characters used to identify, name, or characterize the study.
subgroup_type
subgroup_name		`ncit:C15538`	A group of participants in a research study who all receive the same study treatment. (https://mrctcenter.org/glossaryterm/arm/)
subgroup_assignment_order	`integer`
age_at_subgroup_assignment	`integer`
randomized		`ncit:C25196`	A way to use chance to place study participants into different study treatment groups. (https://mrctcenter.org/glossaryterm/randomization/)

Slot Icons:Required

ClinicalEpisode `0..*`

ClinicalEpisode represents a longitudinal time period such as a disease phase, treatment course, exam, or related episode used to organize observations across diagnosis, treatment, monitoring, and follow-up.

Diagram

Slot	Range	Slot URI	Description
episode_submitter_id	`string`
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_type
disease_phase		`ncit:C168878`	The stage or period of an individual's disease.
course		`ncit:C168807`	The type of protocol treatment course administered.
exam_type
episode_number	`integer`
episode_sequence	`integer`
age_at_start	`integer`
year_at_start	`integer`
age_at_end	`integer`
age_at_course_anc_500	`integer`	`ncit:C168852`	Age of subject (in days) when their neutrophil count exceeded a threshold of 500 (ANC/mm3) during the course.
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
parent_episode_submitter_id	`string`

Slot Icons:Required

Consult `0..*`

Consult captures fertility preservation consultation details, including eligibility, reasons for declining consultation or preservation, participants in the consult, interpreter use, insurance type, and consult outcome.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_fertility_consult	`integer`
fertility_consult_completed
fertility_consult_not_completed_reason
reason_declined_fertility_consult	`string`
reason_declined_fertility_preservation
fertility_consult_who_present
fertility_consult_outcome
interpreter_used
insurance_type

Slot Icons:Required

OffProtocolTherapyOrStudy `0..*`

OffProtocolTherapyOrStudy records when and why a subject went off protocol therapy, off study, or transitioned to another study, preserving study participation and treatment-discontinuation context.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_off	`integer`	`ncit:C168844`	Age of subject (in days) at the last known survival status.
off_type		`ncit:C173256`	The code used to designate that the subject went off therapy or off the study.
reason_off		`ncit:C173519`	The reason a subject went off the therapy or study.
reason_off_other	`string`
another_study		`ncit:C178073`	The subject was enrolled in another therapeutic study after going off the previous study.

Slot Icons:Required

SurvivalCharacteristics `0..*`

SurvivalCharacteristics captures last-known survival status, follow-up timing, disease status at last contact, cause of death, and treatment-related mortality details.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_lkss	`integer`	`ncit:C168844`	Age of subject (in days) at the last known survival status.
age_lost_to_follow_up	`integer`	`ncit:C172679`	Age of subject (in days) when the subject was lost to follow-up.
age_at_last_follow_up	`integer`
lkss		`ncit:C168931`	The individual's last known survival status.
lkss_with_disease		`ncit:C178074`	The last know survival status of the individual with the disease.
cause_of_death		`ncit:C81239`	Cause of death for patient
cause_of_death_other	`string`
trm_type		`ncit:C173260`	The type of treatment related to the mortality of the subject.
trm_type_other	`string`
cause_of_death_detail		`ncit:C168868`	Specific details of the cause of death.
cause_of_death_detail_other	`string`
cause_of_death_ranking		`ncit:C168932`	Assigning a weighted relevance to the cause of death.

Slot Icons:Required

FamilyMedicalHistory `0..*`

FamilyMedicalHistory captures relevant conditions, procedures, reproductive history, lineage, relationship, and survival information for family members or relatives when family history informs disease risk or interpretation.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
condition_state
family_medical_history_condition	`string`	`ncit:C18772`	A collection of information about a person's health. It may include information about allergies, illnesses and surgeries, and dates and results of physical exams, tests, screenings, and immunizations. It may also include information about medicines taken and about diet and exercise.
relation		`ncit:C21480`	A person related by blood or marriage.
relation_lineage
lkss		`ncit:C168931`	The individual's last known survival status.
age_at_lkss	`integer`	`ncit:C168844`	Age of subject (in days) at the last known survival status.
relative_sct_status
number_of_pregnancies	`integer`	`ncit:C106551`	A measurement of the total number of pregnancy events experienced by a female.
number_of_live_births	`integer`	`ncit:C178141`	A measurement of the total number of live-born offspring a female has delivered.
number_of_abortions	`integer`	`ncit:C106550`	A measurement of the total number of instances in which there has been a spontaneous termination of pregnancy (miscarriage) or elective termination of pregnancy.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
family_medical_history_procedure		`ncit:C161601`	A categorization of surgical procedures by type or purpose.
age_at_condition	`integer`	`ncit:C18772`	A collection of information about a person's health. It may include information about allergies, illnesses and surgeries, and dates and results of physical exams, tests, screenings, and immunizations. It may also include information about medicines taken and about diet and exercise.
year_at_pedigree_creation	`integer`

Slot Icons:Required

MedicalHistory `0..*`

MedicalHistory records prior or concurrent conditions and selected background health factors for the subject, supporting interpretation of diagnosis, risk, treatment, and outcomes.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at_condition	`integer`	`ncit:C18772`	A collection of information about a person's health. It may include information about allergies, illnesses and surgeries, and dates and results of physical exams, tests, screenings, and immunizations. It may also include information about medicines taken and about diet and exercise.
condition_state
condition_status
medical_history_condition		`ncit:C18772`	A collection of information about a person's health. It may include information about allergies, illnesses and surgeries, and dates and results of physical exams, tests, screenings, and immunizations. It may also include information about medicines taken and about diet and exercise.
condition_other	`string`	`ncit:C53263`	Relevant elements of medical history, including preexisting medical conditions, events and facts (e.g., allergies, race, pregnancy, smoking and alcohol use, hepatic/renal dysfunction, etc.) not listed in MedWatch form.
assisted_conception
ibd_colon_involvement

Slot Icons:Required

SocialAndBehavioralDeterminantsOfHealth `0..*`

SocialAndBehavioralDeterminantsOfHealth captures selected social, behavioral, exposure, gender identity, occupation, marital, and religious-context variables that may influence care, risk, or outcomes.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_status	`integer`
gender_identity
exposure		`ncit:C17941`	Contact between an agent and a target. A state of contact or close proximity to a medicinal product, chemical, pathogen, radioisotope or other substance. NOTE: Types of exposure may be described by many qualifiers (e.g., local, systemic, acute, chronic, cumulative, environmental, population, individual, gestational, or occupational.) See also exposure (individual), intervention, extent of exposure. [After International Programme on Chemical Safety (IPCS) 2004 WHO]
exposure_amount	`decimal`
exposure_amount_type
exposure_amount_frequency
alcohol_consumption
exposure_status
sunscreen_use
occupation	`string`	`ncit:C25193`	A code specifying the job performed by the employee for the employer. For example, accountant, programmer analyst, patient care associate, staff nurse, etc.
marital_status		`ncit:C25188`	A demographic parameter indicating a person's current conjugal status.
religion_type		`ncit:C17085`	A personal or institutionalized system grounded in belief and reverence for a supernatural power or powers regarded as creator and governor of the universe. (from dictionary.com)
religion_type_other	`string`

Slot Icons:Required

ProviderCharacteristics `0..*`

ProviderCharacteristics captures demographic, training, practice, specialty, procedural volume, and performance characteristics for healthcare providers who treat the patient.

Slot	Range	Slot URI	Description
provider_honest_broker_id	`string`
provider_age_at_survey
provider_data_source
provider_sex
provider_speciality
provider_speciality_other	`string`
hereditary_gi_specialist_status
practice_region	`string`
adenoma_detection_rate	`integer`
adenoma_detection_rate_unit
adenoma_detection_rate_numerator
adenoma_detection_rate_denominator
provider_gender_identity
age_at_training_complete
training_type
training_type_other	`string`
training_country	`string`
practice_location
practice_type
practice_type_other	`string`
practice_hereditary_gi_cancer_patients
lynch_colonoscopy_month
lynch_upper_endoscopy_month
colonoscopy_month
upper_endoscopy_month

Slot Icons:Required

Testing

Testing contains laboratory, pathology, genomic, functional, anthropometric, and specimen-related observations used to characterize subjects, disease biology, eligibility, monitoring, and research sample availability.

VitalsAndAnthropometrics `0..*`

VitalsAndAnthropometrics records physical measurements such as anthropometrics, vital measurements, measurement units, values, and gestational age at birth where relevant.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_measurement	`integer`	`ncit:C154628`	The procedures for measurements of the body's basic functions that provide insight into the health status of the person.
vital_measurement_type		`ncit:C49672`	The act of assessing an individual's current temperature, heart rate, respiratory rate, pulse oxygenation, and blood pressure.
anthropometric_measurement_type		`ncit:C219071`	A set of non-invasive, quantitative measurements of body composition and nutritional status which include height, weight, head circumference, body mass index (BMI), body circumferences, and skinfold thickness.
result_text	`string`	`ncit:C36292`	The outcome of a laboratory test.
result_numeric	`decimal`	`ncit:C185629`	The result of a function test expressed as a number.
vital_measurement_result_unit
anthropometric_measurement_result_unit
gestational_age_at_birth	`integer`	`ncit:C124435`	The gestational age of the subject at birth.

Slot Icons:Required

LaboratoryTest `0..*`

LaboratoryTest captures laboratory assessments and results, including test status, method, specimen, text or numeric result values, units, thresholds, and disease-specific laboratory modifiers.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_lab	`integer`	`ncit:C172691`	Age of subject (in days) when the laboratory test was performed.
laboratory_test_status
laboratory_test		`ncit:C117142`	A character or string that represents the full name of the laboratory assessment.
laboratory_test_method		`ncit:C83312`	A systematic course of action that is performed in order to complete a laboratory test.
laboratory_test_specimen		`ncit:C70713`	The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.
laboratory_test_specimen_other	`string`
laboratory_result		`ncit:C36292`	The outcome of a laboratory test.
result_text	`string`	`ncit:C36292`	The outcome of a laboratory test.
result_numeric	`decimal`	`ncit:C185629`	The result of a function test expressed as a number.
laboratory_test_result_unit
traumatic_tap		`ncit:C168879`	Contamination of a cerebrospinal fluid sample by red blood cells greater than 10/mm3.
quantification_type		`ncit:C49142`	The number of molecules of a particular type on or in a cell or part of a cell. Usually applied to specific genes or to plasmids within a bacterium.
threshold_level
threshold_high	`decimal`	`ncit:C177365`	The maximum level that must be exceeded for a certain reaction to occur or be manifested.
threshold_low	`decimal`	`ncit:C177366`	The minimum level that must be attained for a certain reaction to occur or be manifested.
pmid_ref	`decimal`	`ncit:C127797`	A globally unique identifier for a biomedical article, as assigned by PubMed.
breakage_source_lab
bm_morphology		`ncit:C178079`	The morphology characteristics of the bone marrow blasts.
result_hormone_status		`ncit:C36292`	The outcome of a laboratory test.
laboratory_test_specimen_obtained_method

Slot Icons:Required

GeneticAnalysis `0..*`

GeneticAnalysis captures germline and somatic genomic findings, testing context, specimens, methods, genes, variants, copy number, cytogenetic findings, HGVS expressions, significance, inheritance, and related genomic interpretation fields.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_genetic_analysis	`integer`	`ncit:C168848`	Age of subject (in days) when molecular analysis was performed.
year_at_genetic_analysis	`integer`
review_source		`ncit:C185324`	The institution which has reviewed the lesion assessment.
determination_source
source_lab
test_name	`string`
test_version	`string`
gene_panel_size
cascade_testing		`ncit:C200724`	Genetic screening that is performed on the biological relatives of individuals diagnosed with specific genetic conditions.
genetic_analysis_method		`ncit:C158954`	A request to enter the specific molecular analysis method used to detect abnormalities in the study.
genetic_analysis_method_other	`string`
genetic_analysis_specimen		`ncit:C70713`	The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.
biological_analyte
source_pct
source_pct_numeric	`decimal`
genomic_source_class
mosaicism		`ncit:C92976`	The occurrence of 2 or more cell lines with different genetic or chromosomal make-up, within a single individual or tissue.
mosaicism_percent	`decimal`	`ncit:C92976`	The occurrence of 2 or more cell lines with different genetic or chromosomal make-up, within a single individual or tissue.
alteration_presence		`ncit:C173596`	An indicator for whether a molecular analysis procedure was performed and whether the assay detected a molecular abnormality.
alteration		`ncit:C3910`	A molecular or cytogenetic abnormality which occurs in either human disease states or disease models.
alteration_type		`ncit:C13202`	A structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication. [Sequence Ontology: SO:0000340 (SOWiki) http://www.sequenceontology.org/browser/current_svn/term/SO:0000340] EXAMPLE(S): Most humans have 23 pairs of chromosomes--22 pairs of numbered chromosomes, called autosomes, and one pair of sex chromosomes, X and Y. OTHER NAME(S): NOTE(S): This class can represent eukaryotic (e.g. human), mitochondrial, bacterial, and viral chromosomes, for example.
alteration_effect		`ncit:C204195`	The effect of a sequence change on the function of an RNA, DNA, or protein.
alteration_region
chromosome		`ncit:C13202`	A structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication. [Sequence Ontology: SO:0000340 (SOWiki) http://www.sequenceontology.org/browser/current_svn/term/SO:0000340] EXAMPLE(S): Most humans have 23 pairs of chromosomes--22 pairs of numbered chromosomes, called autosomes, and one pair of sex chromosomes, X and Y. OTHER NAME(S): NOTE(S): This class can represent eukaryotic (e.g. human), mitochondrial, bacterial, and viral chromosomes, for example.
chromosomal_translocation_partner
cytoband	`string`	`ncit:C13202`	A structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication. [Sequence Ontology: SO:0000340 (SOWiki) http://www.sequenceontology.org/browser/current_svn/term/SO:0000340] EXAMPLE(S): Most humans have 23 pairs of chromosomes--22 pairs of numbered chromosomes, called autosomes, and one pair of sex chromosomes, X and Y. OTHER NAME(S): NOTE(S): This class can represent eukaryotic (e.g. human), mitochondrial, bacterial, and viral chromosomes, for example.
iscn	`string`	`ncit:C156450`	An international standard for human chromosome nomenclature, which includes band names, symbols and abbreviated terms used in the description of human chromosome and chromosome abnormalities.
gene	`string`	`ncit:C173595`	The gene symbol that represents either a single gene that has a mutation or the gene that comprises the 5' portion of the coding sequence involved in a fusion gene mutation.
gene_fusion_partner	`string`	`ncit:C171253`	The gene symbol that represents the gene that comprises the 3' portion of the coding sequence for a fusion gene.
exon_number	`decimal`
hgvs_genomic_transcript	`string`
hgvs_genomic	`string`
hgvs_coding_transcript	`string`
hgvs_coding	`string`	`ncit:C198546`	The designation of a DNA coding sequence variation based on the Human Genome Variation Society (HGVS) nomenclature guidelines.
hgvs_protein_transcript	`string`
hgvs_protein	`string`	`ncit:C97928`	A variation in the sequence of a specific gene product.
reference_genome	`string`	`ncit:C164815`	The source-specific version of the genome assembly. EXAMPLE(S): (Human Genome) Build 35 OTHER NAME(S): NOTE(S):
reference_genome_accession	`string`
parental_status
inheritance_pattern		`ncit:C45827`	The manner in which a genetic trait or disorder is passed from one generation to the next. Autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive, multifactorial, and mitochondrial inheritance are examples. Each mode of inheritance results in a characteristic pattern of affected and unaffected family members.
reported_significance
reported_significance_numeric	`integer`
reported_significance_other	`string`
external_ref_id_system
external_ref_id	`string`
copy_number	`decimal`	`ncit:C49142`	The number of molecules of a particular type on or in a cell or part of a cell. Usually applied to specific genes or to plasmids within a bacterium.
maf
maf_numeric	`decimal`	`ncit:C173545`	The determination of the ratio of variant alleles to wild-type alleles present in a sample.
vaf_numeric	`decimal`
dna_index
dna_index_numeric	`decimal`	`ncit:C86972`	The ratio of the DNA content or chromosome number in a tumor sample compared to that in a normal sample.
allelic_state
allele_count	`decimal`
allelic_ratio	`decimal`	`ncit:C173545`	The determination of the ratio of variant alleles to wild-type alleles present in a sample.
clonal_status
cytodifferentiation
mitotic_rate		`ncit:C138982`	A score assigned to a biopsy sample to indicate the number of mitotic cells present in a tumor.
alt_status
founder_population
acmg_based_significance
karyotype_status		`ncit:C168871`	The status of the subject's karyotype.
total_chromosomes	`decimal`	`ncit:C177370`	The number of chromosomes upon karyotype analysis.
independent_aberrations	`decimal`	`ncit:C173279`	The number of independent aberrations found in the karyotype during analysis.
cells_in_metaphase	`decimal`	`ncit:C168918`	The number of cells in metaphase during karyotype analysis.
associated_condition
genetic_analysis_indication

Slot Icons:Required

Biospecimen `0..*`

Biospecimen describes collected or stored biospecimens, including specimen type, container, media, and available quantity, supporting specimen tracking and downstream research use.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
biospecimen_container_id	`string`
age_at_collection	`integer`
biospecimen_container_type	`string`
biospecimen_media	`string`
biospecimen_type	`string`
biospecimen_tissue_type	`string`
biospecimen_site	`string`
biospecimen_preservation_method	`string`
biospecimen_storage_temperature	`decimal`
current_qty_unit	`string`
current_qty_value	`string`
specimen_gross_dimension	`decimal`
specimen_dimension_unit	`string`
specimen_fragment_count	`integer`

Slot Icons:Required

FunctionTest `0..*`

FunctionTest captures functional assessments such as audiology, pulmonary, cardiac, neurologic, or other function-related tests, including result values, units, laterality, grade, and frequency-specific measurements.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_function_test	`integer`	`ncit:C185624`	Age of subject (in days) at the time of the function test.
function_test		`ncit:C186304`	The test of the function of an organ or body system.
functional_measurement_type		`ncit:C185625`	A grouping of items based on their function.
result_text	`string`	`ncit:C36292`	The outcome of a laboratory test.
result_numeric	`decimal`	`ncit:C185629`	The result of a function test expressed as a number.
functional_measurement_result_unit
function_test_laterality
hz_frequency
average_loss_low	`decimal`
average_loss_high	`decimal`
function_test_grade

Slot Icons:Required

Immunohistochemistry `0..*`

Immunohistochemistry captures marker-level IHC testing, review source, age at assessment, and text or numeric results for pathology-based disease characterization.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_ihc	`integer`	`ncit:C175006`	Age of subject (in days) at immunohistochemistry assessment.
ihc_method
review_source		`ncit:C185324`	The institution which has reviewed the lesion assessment.
markers		`ncit:C51944`	A diagnostic test in which an antibody is used to link a cellular antigen specifically to a stain that can be seen with a microscope.
result_text	`string`	`ncit:C36292`	The outcome of a laboratory test.
result_numeric	`decimal`	`ncit:C185629`	The result of a function test expressed as a number.
ihc_result_unit

Slot Icons:Required

Disease Attributes

Disease Attributes contains diagnostic, staging, anatomic, histologic, biologic, risk, extent-of-disease, and disease-site concepts used to characterize the subject's cancer or cancer-related condition.

Diagnosis `1..*`

Diagnosis captures disease diagnosis and diagnostic assessment details, including timing, review source, diagnosis basis, diagnosis category, morphology, histology, disease-specific diagnostic flags, and transformation information.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_diag_assessment	`integer`	`ncit:C175004`	Age of subject (in days) at histology assessment.
year_at_diagnosis	`integer`
age_at_diag_resolved	`integer`
biospecimen_container_id	`string`
review_source		`ncit:C185324`	The institution which has reviewed the lesion assessment.
determination_source
evaluator		`ncit:C51824`	A person who determines the significance, worth, or condition of something by careful appraisal and study.
diagnosis_site		`ncit:C157120`	The anatomic site of the tumor.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
diagnosis_category
diagnosis_basis
suspected_referring_diagnosis
diagnosis		`ncit:C15220`	A process to identify the disease, condition, or injury that explains the symptoms and signs occurring in a patient.
cns_disease_status		`ncit:C116832`	The status describing the extent of central nervous system involvement at the time of leukemia diagnosis.
mpal		`ncit:C82179`	An acute leukemia of ambiguous lineage. It is characterized by the presence of either separate populations of blasts of more than one lineage, or one population of blasts co-expressing markers of more than one lineage.
mlds		`ncit:C43223`	Acute myeloid leukemia occurring in children with Down syndrome. During the first 3 years of life, it is usually the megakaryoblastic subtype, and is associated with GATA1 gene mutation. After age 4 this is no longer the case.
tam		`ncit:C82339`	A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.
secondary_aml		`ncit:C25765`	An acute myeloid leukemia arising from prior myelodysplastic syndrome, myeloproliferative neoplasm, or myelodysplastic/myeloproliferative neoplasm, or as a result of previous exposure to alkylating agents or topoisomerase II inhibitors.
result_text	`string`	`ncit:C36292`	The outcome of a laboratory test.
result_numeric	`decimal`	`ncit:C185629`	The result of a function test expressed as a number.
path_morph_reporting	`string`
morph_code_text	`string`
morph_code	`string`
morph_code_system
morph_code_system_version	`string`
diagnosis_conf_source
transformation
transformation_conf_source
mature_glial_implants		`ncit:C177363`	A nodule of mature glial tissue that develops in the peritoneum. It is usually accompanied by mature or immature ovarian teratoma.
somatic_malignancy_type		`ncit:C177364`	A malignant non-germ cell component that typically develops secondarily within a germ cell tumor. The malignant cellular component is usually sarcomatous or carcinomatous.
histology_grade		`ncit:C18000`	A description of a tumor based on how abnormal the cancer cells look under a microscope and how quickly the tumor is likely to grow and spread. Grading systems are different for each type of cancer.
revised_inpc
histologic_features
diagnosis_context
dysplasia		`ncit:C4086`	A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer.

Slot Icons:Required

Staging `0..*`

Staging captures stage, group, TNM, disease extent, and staging-system details used to summarize disease burden and classification at a defined time point.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_staging	`integer`	`ncit:C177359`	Age of subject (in days) at the time of the staging assessment.
review_source		`ncit:C185324`	The institution which has reviewed the lesion assessment.
staging_site		`ncit:C157120`	The anatomic site of the tumor.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
stage_category		`ncit:C15608`	Performing exams and tests to learn the extent of the cancer within the body, especially whether the disease has spread from the original site to other parts of the body. It is important to know the stage of the disease in order to plan the best treatment.
tnm_finding
tnm_tumor_t
tnm_node_n
tnm_metastasis_m
tnm_overall
h_stage
group_system
group
stage_system		`ncit:C18004`	A systematic method for clinicopathologic evaluation of tumors.
stage_system_version	`string`
stage		`ncit:C16899`	The extent of a cancer in the body.
stage_text	`string`
disease_extent
ann_arbor_mod_ab		`ncit:C181839`	An indication whether A- or B-designations, based on the Ann Arbor lymphoma classification system guidelines, were used to modify staging classifications.
ann_arbor_mod_e		`ncit:C177586`	An indication of whether a record includes data regarding extranodal involvement based on the Ann Arbor lymphoma classification system guidelines.
ann_arbor_mod_s		`ncit:C185484`	An indication of whether a record includes data regarding splenic involvement based on the Ann Arbor lymphoma classification system guidelines.
pretext_mod_v
pretext_mod_p
pretext_mod_e
pretext_mod_m
pretext_mod_f
pretext_mod_r
kaposi_sarcoma_t		`C134970`	A term that refers to the tumor status of AIDS-related Kaposi sarcoma according to the AIDS Clinical Trials Group system. (American Cancer Society)
kaposi_sarcoma_i		`C134978`	A term that refers to the immune system status of AIDS-related Kaposi sarcoma according to the AIDS Clinical Trials Group system. The immune status is assessed using the CD4 count test. (American Cancer Society)
kaposi_sarcoma_s		`C134981`	A term that refers to the systemic illness status of AIDS-related Kaposi sarcoma according to the AIDS Clinical Trials Group system. (American Cancer Society)
skip_lesion		`ncit:C174454`	A benign or malignant pathologic process which is patchy and skips areas which are normal (uninvolved by the pathologic process).

Slot Icons:Required

DiseaseSiteAssessment `0..*`

DiseaseSiteAssessment captures assessment of tumors, lesions, nodes, sites of disease, measurements, laterality, detection methods, anatomic coding, and disease-specific site findings.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_disease_site_assessment	`integer`	`ncit:C174997`	Age of subject (in days) at tumor assessment.
provider_honest_broker_id	`string`
biospecimen_container_id	`string`
review_source		`ncit:C185324`	The institution which has reviewed the lesion assessment.
tumor_state
detection_method		`ncit:C173262`	The method used to detect the extent of the disease involvement.
mri_sequence
site_classification		`ncit:C174459`	The classification of a tumor based primarily on histopathological characteristics.
disease_presence
assessment_reason		`ncit:C171003`	The explanation for why a test, measurement, or assessment is executed.
disease_site		`ncit:C166232`	Specifies the anatomic site of a localized pathological or traumatic structural change, damage, deformity, or discontinuity of tissue, organ, or body part.
site_other	`string`
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
measurement1	`decimal`	`ncit:C96684`	The longest possible length of a straight line passing through the center of a circular or spheroid object that connects two points on the circumference.
measurement1_axis
measurement2	`decimal`	`ncit:C96684`	The longest possible length of a straight line passing through the center of a circular or spheroid object that connects two points on the circumference.
measurement2_axis
measurement3	`decimal`	`ncit:C16809`	A procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. These pictures can show the difference between normal and diseased tissue. NMRI makes better images of organs and soft tissue than other scanning techniques, such as computed tomography (CT) or x-ray. NMRI is especially useful for imaging the brain, the spine, the soft tissue of joints, and the inside of bones.
measurement3_axis
measurement_unit
nodes_assessed_number	`integer`
myeloid_sarcoma_involvement
bulky_disease		`ncit:C38655`	The presence of a large mass or matted lymph nodes in an imaging study. This term almost always refers to lymphomas and its definition depends on the histological type of lymphoma. Generally, a tumor mass measuring more than 7 cm or more than 10 cm in diameter is considered bulky disease.
bulk_med_mass		`ncit:C178075`	When the maximum width of a mass is equal or greater than one-third of the internal transverse diameter of the thorax at the level of T5/6 on a PA CXR. Bulk at an alternate site is defined as any mass measuring 10 cm or more by any imaging study.
pleural_effusion		`ncit:C3331`	A disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.
pericardial_effusion		`ncit:C3319`	A disorder characterized by fluid collection within the pericardial sac, usually due to inflammation.
bulk_nodal_aggregate		`ncit:C185476`	Bulk at an alternate site to the thorax defined as any mass measuring 10 cm or more by any imaging study.
med_ratio	`decimal`	`ncit:C185323`	A measurement of the width of the mediastinum divided by the width of the chest.
nodular_splenic		`ncit:C185322`	A finding indicating that Hodgkin lymphoma has spread to the spleen focally and there is associated involvement of the hilar lymph nodes.
tumor_size
tumor_number	`decimal`
invasiveness
depth		`ncit:C25333`	The extent downward or inward; the perpendicular measurement from the surface downward to determine deepness.
nodal_pathology
nodal_clinical
parameningeal_extension
top_code	`string`
top_code_text	`string`
top_code_system
top_code_system_version	`string`
tumor_presentation
tissue_type		`ncit:C119940`	The type of material sample taken from a biological entity for tumor findings assessment testing.
multiplicity
tumor_volume		`ncit:C94515`	The size of a cancer measured by the amount of space taken up by the tumor. For example, the tumor volume of prostate cancer is the percentage of the prostate taken up by the tumor.
estimated_volume	`decimal`
fracture		`ncit:C3046`	A finding of traumatic injury to the bone in which the continuity of the bone is broken.
ipsilateral_nodules		`ncit:C174455`	A metastatic tumor nodule located in the same side of the organ in which the primary tumor occurred.
joint_involvement		`ncit:C174453`	A finding indicating the spread of cancer to a joint.
site_within_bone		`ncit:C174998`	The anatomic site within the bone.
dysplasia		`ncit:C4086`	A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer.
hpv_status
extension_tumor_type
visual_discrete_tumors
number_of_tumors_numeric	`decimal`
tumor_from_fovea
optic_nerve_obscuration
optic_nerve_obscuration_degree
tumor_from_optic_nerve
fluid_from_tumor
seeds_present
seeds_pattern
seeds_type
seeds_classification
finding
colon_polyp_size
tumor_budding
number_nodes_examined_numeric	`decimal`	`ncit:C124446`	The number of lymph nodes that were examined.
colon_polyps_total	`decimal`
gastric_polyps_total	`decimal`
small_bowel_polyps_total	`decimal`
site_finding
volume	`decimal`
volume_unit
endometrial_stripe_thickness	`decimal`
endometrial_stripe_thickness_unit
sedation_type
endoscope_adjunct_technique
endoscope_adjunct_technique_other	`string`
insertion_time	`integer`
insertion_time_unit
withdrawal_time	`integer`
withdrawal_time_unit
total_procedure_time	`integer`
total_procedure_time_unit
all_mucosa_visualized
bowel_preparation		`ncit:C62659`	Purging and cleansing of fecal and other matter from the bowel to assure subsequent clear evaluation of the bowel or to limit complications due to accidental surgical bowel perforation.
bbps_score_left
bbps_score_right
bbps_score_transverse
insertion_extent
polyp_morphology
polyp_morphology_system
finding_status
surveillance_recommendation

Slot Icons:Required

DiseaseCharacteristics `0..*`

DiseaseCharacteristics captures additional disease-level attributes such as risk group, imaging response scores, performance status, clinical findings, presentation symptoms, and disease-specific biologic or clinical characteristics.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_disease_characteristic	`integer`
disease_characteristics_site		`ncit:C157120`	The anatomic site of the tumor.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
detection_method		`ncit:C173262`	The method used to detect the extent of the disease involvement.
risk_group
gts_treatment		`ncit:C177376`	The therapy chosen to treat Growing Teratoma Syndrome.
imaging_result		`ncit:C176708`	The result of an evaluation technique using a visual display of structural or functional patterns of organs or tissues that is performed to determine the presence, absence, or degree of a condition.
deauville_score		`ncit:C99723`	A 5 point scale originally devised by Barrington et al. (2014) to assess the response to treatment of lymphoma by FDG-PET scanning, and has since been validated to assess treatment responses in a number of additional solid and non-solid tumors.
qpet_score	`decimal`	`ncit:C185623`	A methodology that provides semi-automatic quantification for interim FDG-PET response in lymphoma. It extends the ordinal Deauville score to a continuous scale.
performance_score
physical_status
initial_treatment_category
mki
vacterlh
phenos
vacterlh_phenos_status
clinical_finding
clinical_finding_other	`string`
modified_rankin_scale	`integer`	`ncit:C111383`	A standardized clinical classification originally developed by John Rankin in 1957, and later modified by Van Swieten et al in 1988, which is used to assess the degree of disability or dependence in the daily activities of individuals who have suffered a stroke. It also allows comparison between subjects with different kinds of neurologic deficits. The questionnaire contains a '0 to 6' scale, ranging from 'no symptoms at all' (scored 0) to 'dead' (scored 6).
fans_symptom_acuity
skip_met_involvement		`ncit:C186745`	A question about the areas involved in the skip metastasis.
trilateral_retinoblastoma		`ncit:C7019`	Trilateral retinoblastoma refers to bilateral (or less often unilateral) retinoblastoma associated with an intracranial primitive neuroectodermal tumor in the pineal or suprasellar region. This syndrome is often associated with a increased familial incidence of retinoblastoma. (From Cancer 86(1): 135-141, 1999).
presentation_symptoms
presentation_symptoms_status
anterior_segment_exam
retinal_detachment
prior_steroids_week
prior_steroids_month
gonadotoxic_risk
gonadotoxic_risk_system	`string`
gonadotoxic_risk_system_version	`string`

Slot Icons:Required

Intervention

Intervention contains treatment and procedure records, including surgery, medications, radiation therapy, transplantation, transfusion, cellular therapy, locoregional therapy, fertility preservation procedures, and protocol treatment modifications.

SurgicalProcedures `0..*`

SurgicalProcedures records biopsy, resection, procedural, and surgery-related interventions, including site, laterality, extent, margins, complications, outcome, and disease-specific surgical details.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_procedure	`integer`	`ncit:C175008`	Age of subject (in days) at procedure.
protocol_procedure		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
non_protocol_timing		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
procedure_timing
procedure_performed
site_classification		`ncit:C174459`	The classification of a tumor based primarily on histopathological characteristics.
procedure		`ncit:C161601`	A categorization of surgical procedures by type or purpose.
procedure_other	`string`
procedure_method
procedure_site		`ncit:C157120`	The anatomic site of the tumor.
site_other	`string`
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
extent		`ncit:C157443`	A description of the relative amount of tissue, blood vessel, or organ that has been removed.
mass_present
viable_tumor_specimen
viable_tumor_margin
margins		`ncit:C41227`	One of the criteria for assessment of the effectiveness of given surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. It is defined by the tissue plane through which the dissection has been done and the actual or potential neoplastic tissue which has been left outside the boundary of a resected specimen within the patient. There are four types of surgical margins: intracapsular or intralesional, marginal, wide, and radical.
number_nodes		`ncit:C185516`	A question whether an individual has a single or multiple lymph nodes involved.
number_nodes_numeric	`decimal`	`ncit:C124446`	The number of lymph nodes that were examined.
purpose		`ncit:C185526`	The reason a procedure is performed.
nephron_sparing_partial_nephrectomy
tumor_rupture
surgical_complications		`ncit:C164157`	A disease or disorder that occurs during, soon after or as a result of a surgical procedure.
surgical_complications_other	`string`
outcome		`ncit:C49489`	A condition or event that is attributed to the adverse event and is the result or conclusion of the adverse event.
hydrocephalus		`ncit:C3111`	A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain.
posterior_fossa_syndrome
csf_diversion
procedure_extent		`ncit:C157443`	A description of the relative amount of tissue, blood vessel, or organ that has been removed.
distance_from_margin	`decimal`	`ncit:C137815`	The distance of the closest surgical margin from tumor after surgical resection of the tumor. The closest distance between a tumor and its resection margin has prognostic significance.
laser_type
laser_power
laser_duration
laser_duration_numeric	`decimal`
cryotherapy_freezes	`integer`
freeze_thaw_cycle_number	`integer`
remaining_colon

Slot Icons:Required

Medication `0..*`

Medication captures medication exposure and administration details, including chemotherapy or supportive care agents, regimen, route, dose, frequency, cumulative exposure, timing, and protocol or non-protocol context.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_medication_start	`integer`	`ncit:C172698`	Age of subject (in days) at the start of the total dose calculation.
age_at_medication_end	`integer`	`ncit:C172686`	Age of subject (in days) at the end of the total dose calculation.
year_at_medication_start	`integer`
medication_administration_status		`ncit:C173297`	The status of the medication administration.
cycles_planned	`decimal`
cycle_number	`decimal`	`ncit:C166208`	The number of the individual chemotherapeutic cycle.
session_number	`integer`
protocol_medication		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
non_protocol_timing		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
non_protocol_reason
medication_category		`ncit:C459`	A drug given to a patient to mitigate or cure an illness, injury, or reduced health status. See also drug, treatment, intervention.
supportive_care_detail
route		`ncit:C186559`	The intended area to be affected by the choice of a particular route of administration of a medication.
medication		`ncit:C459`	A drug given to a patient to mitigate or cure an illness, injury, or reduced health status. See also drug, treatment, intervention.
medication_other	`string`
regimen		`ncit:C15697`	A description of the schedule and periodicity of a treatment or vaccination regimen.
administration_site
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
number_doses	`decimal`	`ncit:C173293`	The total number of doses administered to the patient over the defined period of time.
medication_dose_administered	`decimal`	`ncit:C94394`	In medicine, the total amount of a drug or radiation given to a patient over time; for example, the total dose of radiation given in a series of radiation treatments.
medication_dose_intended	`decimal`	`ncit:C173294`	The total amount of the medication intended to be administered to the patient over the defined period of time.
medication_dose_unit		`ncit:C17395`	Phase of the cell cycle following G1 and preceding G2 when the entire DNA content of the nucleus is replicated (Synthesis phase). It is achieved by bidirectional replication at multiple sites along each chromosome.
frequency
frequency_other	`string`
total_dose_given
delivery_status
lifetime_cumulative_dose	`decimal`
lifetime_cumulative_dose_unit

Slot Icons:Required

LocoregionalTherapy `0..*`

LocoregionalTherapy captures localized treatment approaches such as embolization or ablation, including technique, dose, administration status, and timing.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_locoregional_therapy	`integer`
locoregional_therapy_administration_status		`ncit:C173297`	The status of the medication administration.
locoregional_therapy_technique
locoregional_therapy_dose	`decimal`
locoregional_therapy_dose_unit

Slot Icons:Required

ProtocolTreatmentModifications `0..*`

ProtocolTreatmentModifications captures changes to planned protocol therapy, including modification type, basis, reason, toxicity details, and agent substitutions.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_modification	`integer`
modification		`ncit:C185632`	The kind of modification.
modification_other	`string`
modification_basis		`ncit:C93529`	The rationale for why an entity or event is changed.
reason		`ncit:C185636`	The rationale for why an entity or event is changed.
reason_other	`string`
toxicity_detail		`ncit:C185693`	Information about the conditions surrounding the toxicity.
toxicity_detail_other	`string`
toxicity_immune		`ncit:C63814`	Toxicity that impairs or damages the immune system.
toxicity_infusion		`ncit:C185649`	Toxicity related to an infusion.
original_agent		`ncit:C185650`	The first agent planned for a therapy.
original_agent_other	`string`
sub_agent		`ncit:C185634`	A medication was substituted with another.
sub_agent_other	`string`

Slot Icons:Required

RadiationTherapy `0..*`

RadiationTherapy captures radiation treatment timing, site, technique, energy type, dose, fractions, boosts, treatment volume, brachytherapy or plaque details, shielding, and protocol context.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_rt_start	`integer`	`ncit:C172695`	Age of subject (in days) at the start of radiation therapy.
year_at_rt_start	`integer`
age_at_rt_end	`integer`	`ncit:C172696`	Age of subject (in days) at the end of radiation therapy.
rt_administration_status		`ncit:C173297`	The status of the medication administration.
indication
protocol_radiation_therapy		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
non_protocol_timing		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
rt_data_source
site_classification		`ncit:C174459`	The classification of a tumor based primarily on histopathological characteristics.
rt_site		`ncit:C173281`	The anatomic site of the radiation therapy.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
energy_type		`ncit:C15313`	Patient required additional radiation therapy.
technique		`ncit:C15313`	Patient required additional radiation therapy.
rt_dose	`decimal`	`ncit:C173282`	The total radiation dose administered.
rt_dose_unit		`ncit:C18068`	A unit of measurement of the dose of radiation received or absorbed.
boost_type		`ncit:C137812`	One or more extra radiation treatments targeted at the tumor bed, given after the regular sessions of radiation are complete.
boost_dose	`decimal`	`ncit:C185679`	The dose amount of the radiation boost.
num_fraction	`integer`	`ncit:C175034`	The number of divided radiation doses received per day.
fraction_dose	`decimal`
fraction_dose_unit		`ncit:C18068`	A unit of measurement of the dose of radiation received or absorbed.
apex_dose	`decimal`
dose_rate_at_apex	`decimal`
treatment_volume
rt_margins		`ncit:C41227`	One of the criteria for assessment of the effectiveness of given surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. It is defined by the tissue plane through which the dissection has been done and the actual or potential neoplastic tissue which has been left outside the boundary of a resected specimen within the patient. There are four types of surgical margins: intracapsular or intralesional, marginal, wide, and radical.
transposition_organ		`ncit:C175035`	A procedure to move organs out of the range of the damaging effects of radiation.
rt_completed
plaque_size
rad_seeds_type
rad_seeds_num	`decimal`
plaque_source
plaque_model	`string`
reporting_level
brach_calc_type
implant_duration	`decimal`
suture_coordinates	`string`
shielding

Slot Icons:Required

StemCellTransplant `0..*`

StemCellTransplant records hematopoietic stem cell transplant details, including timing, transplant type, donor relationship, HLA matching, conditioning, cell source, CD34 collection or infusion, chimerism, and recovery status.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_sct	`integer`	`ncit:C168853`	Age of subject (in days) at the time of stem cell transplantation.
year_at_sct	`integer`
age_at_sct_harvest	`integer`	`ncit:C198866`	The age of subject at the time of stem cell harvest.
age_at_recovery	`integer`	`ncit:C113053`	Recovery and purification of stem cells from human sources, including umbilical cord blood.
sct_status
non_protocol_timing		`ncit:C175038`	A description of the timing of when the non-protocol therapy was received.
protocol_sct
sct_type		`ncit:C168864`	Type of stem-cell transplantation the subject received.
stem_cell_source		`ncit:C168870`	The source of the stem cells for the stem cell transplant.
donor_relationship		`ncit:C168869`	The biological relationship between the stem cell donor and the recipients.
hla_match		`ncit:C169009`	A process in which blood or tissue samples are analyzed to determine their human leukocyte antigen (HLA) profiles so that transplant materials can be transferred into a patient with the same or similar profile.
number_hla	`decimal`	`ncit:C173301`	The number of human leukocyte antigens that were evaluated.
number_matches	`decimal`	`ncit:C173302`	The number of human leukocyte antigens that matched between the donor and the recipient.
hla_a_result		`ncit:C168923`	The extent of HLA-A matching between the donor and the recipient.
hla_b_result		`ncit:C168924`	The extent of HLA-B matching between the donor and the recipient.
hla_c_result		`ncit:C168925`	The extent of HLA-C matching between the donor and the recipient.
hla_drb1_result		`ncit:C168926`	The extent of HLA-DRB1 matching between the donor and the recipient.
hla_dq_result		`ncit:C168927`	The extent of HLA-DQ matching between the donor and the recipient.
conditioning_type		`ncit:C169014`	Type of conditioning the subject received prior to stem-cell transplantation.
prior_tbi		`ncit:C15350`	A procedure involving irradiation of the whole body.
total_cycles	`decimal`	`ncit:C177373`	The total number of stem cell transplant cycles.
recovery_type
recovery_status
cd34_collected	`decimal`	`ncit:C175036`	The determination of the amount of CD34 expressing stem cells present in a sample.
cd34_transplant	`decimal`	`ncit:C175037`	The determination of the amount of transplanted CD34 expressing stem cells.
chimerism	`decimal`
chimerism_unit
sct_success
stem_cell_processing
stem_cell_processing_other	`string`

Slot Icons:Required

TransfusionMedicineProcedure `0..*`

TransfusionMedicineProcedure captures transfusion or transfusion-medicine procedures, including product type, procedure type, number of units, and timing.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_tmp_start	`integer`	`ncit:C172697`	Age of subject (in days) at the start of the transfusion procedure.
tmp_type		`ncit:C173057`	An infusion or replacement of blood components.
tmp_product		`ncit:C173287`	The type of product intended for transfusion.
product_type		`ncit:C185655`	The type of processing that is used on the transfusion product.
number_units	`decimal`	`ncit:C185656`	The number of units transfused into an individual.

Slot Icons:Required

CellularImmunotherapy `0..*`

CellularImmunotherapy captures cellular immunotherapy infusions or related immune effector cell interventions and their timing and therapy type.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_cimt_start	`integer`	`ncit:C173195`	Age of subject (in days) at the start of the cellular immunotherapy.
cimt_type		`ncit:C173057`	An infusion or replacement of blood components.

Slot Icons:Required

FertilityProcedures `0..*`

FertilityProcedures captures fertility preservation procedures and reproductive tissue handling, including collection, cryopreservation, oocyte, embryo, semen, testicular, ovarian, and surgical procedure details.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_fertility_procedure	`integer`
fertility_procedure
procedure_class
tissue_type		`ncit:C119940`	The type of material sample taken from a biological entity for tumor findings assessment testing.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
transport_media
transport_media_other	`string`
cryopreservation_media
cryopreservation_media_other	`string`
freezing_method
freezing_method_other	`string`
monitor_method
retrieval_method
collection_status
cryopreservation_status
oocyte_collection_attempts	`integer`
oocyte_retrieved_numeric	`integer`
mature_oocytes_numeric	`integer`
oocytes_fertilized_numeric	`decimal`
fertilization_rate	`decimal`
maturity_rate	`decimal`
cryopreserved_embryo_numeric	`decimal`
cryopreserved_oocyte_numeric	`decimal`
embryo_cryopreserved_day	`integer`
embryo_vitrification_stage
menstrual_phase
preimplantation_genetic_testing
preimplantation_genetic_testing_type
semen_volume	`decimal`
semen_concentration	`decimal`
semen_motility	`decimal`
semen_morphology	`decimal`
semen_count	`decimal`
semen_motility_count	`decimal`
semen_abnormality
cryopreserved_semen_vials_numeric	`decimal`
semen_cryopreservation_attempts	`decimal`
testicular_tissue_weight_processed	`integer`
testicular_tissue_weight_unit
testicular_tissue_pieces_cryopreserved	`integer`
testicular_tissue_vials_cryopreserved	`integer`
sperm_present
surgeon_type
otc_surgical_technique
otc_conversion_reason
otc_surgical_energy_source
germ_cells_present_spermatogonia
spermatogonia_density	`decimal`
spermatogonia_density_unit
germ_cells_present_follicles
follicle_density	`decimal`
follicle_density_unit
ovary_resect_percent	`decimal`
otc_vials_number	`integer`
otc_strips_number	`integer`
otc_strips_weight	`decimal`
otc_strips_weight_unit

Slot Icons:Required

Monitoring

Monitoring contains response, residual disease, toxicity, late effects, subsequent neoplasms, reproductive outcomes, patient-reported outcomes, and other follow-up concepts used to evaluate disease course and treatment impact over time.

SubjectResponse `0..*`

SubjectResponse captures response assessments across disease sites and treatment time points, including response methods, categories, systems, scores, marrow findings, imaging findings, necrosis, symptoms, and disease-specific response details.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_response	`integer`	`ncit:C168856`	Age of subject (in days) when the response assessment was made.
response_site		`ncit:C157120`	The anatomic site of the tumor.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
cycle_number	`decimal`	`ncit:C166208`	The number of the individual chemotherapeutic cycle.
tx_prior_response
response_method		`ncit:C178148`	The method used to assess the response to therapy.
response_category		`ncit:C173306`	The category used to assess the response to therapy.
response_system		`ncit:C125932`	A standard from which a judgment concerning tumor response to therapy can be established.
response_system_version	`string`	`ncit:C175042`	The version of the response system.
response		`ncit:C50995`	Status of the disease treated with radiation therapy at the time of the record.
mibg_score_type
mibg_score	`decimal`
bm_pct_blasts_at_response	`decimal`	`ncit:C168959`	The percent of cells that were blasts in the subject's bone marrow used to make the response assessment.
bm_analysis_method_at_response		`ncit:C168960`	The modality used to determine the bone marrow percent blasts.
anc_at_response	`decimal`	`ncit:C168961`	The absolute neutrophil count used to make the response assessment.
anc_threshold_at_response		`ncit:C168962`	Subject exceeded an absolute neutrophil count threshold of >= 500 (ANC/mm3) at the time of the response assessment.
platelet_count_at_response	`decimal`	`ncit:C168963`	The platelet count used to make the response assessment.
platelet_threshold_at_response		`ncit:C168964`	Subject exceeded a platelet count threshold of >=50,000 (platelets/mm3) at the time of the response assessment.
interim_response		`ncit:C185657`	An evaluation prior to the completion of therapy that the individual is responding to therapy.
pct_change	`decimal`	`ncit:C185497`	The percentage of change in a particular lesion.
symptoms_at_response		`ncit:C25269`	Exhibiting the symptoms of a particular disease.
palpable_nodes		`ncit:C185660`	The lymph nodes are felt on palpation.
nodular_splenic		`ncit:C185322`	A finding indicating that Hodgkin lymphoma has spread to the spleen focally and there is associated involvement of the hilar lymph nodes.
necrosis		`ncit:C159481`	A quantitative measurement of the percent of cells undergoing necrosis compared to the number of total cells present in a sample.
necrosis_pct	`decimal`	`ncit:C159481`	A quantitative measurement of the percent of cells undergoing necrosis compared to the number of total cells present in a sample.
mri_sequence
neurological_status
anaplasia
anaplasia_type
anaplasia_pct_numeric	`decimal`

Slot Icons:Required

MinimalResidualDisease `0..*`

MinimalResidualDisease captures MRD assessments, including method, specimen, result text or numeric value, unit, assay sensitivity, and molecular markers.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_mrd_assessment	`integer`	`ncit:C168855`	Age of subject (in days) at assessment of minimal residual disease.
mrd_method		`ncit:C168933`	Modality used to determine minimal residual disease.
result_text	`string`	`ncit:C36292`	The outcome of a laboratory test.
result_numeric	`decimal`	`ncit:C185629`	The result of a function test expressed as a number.
mrd_result_unit
sensitivity	`decimal`	`ncit:C168957`	Sensitivity of modality used to determine minimal residual disease.
mrd_specimen		`ncit:C168958`	Source of sample used for minimal residual disease assessment.
molecular_markers		`ncit:C168895`	A one or more molecular characteristics that are used as a biomarker for minimal residual disease.

Slot Icons:Required

ReproductiveAndPubertalStatus `0..*`

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_assessment	`integer`
female_pubertal_status		`ncit:C204694`	An indication as to whether the individual's first menstruation event has occurred.
male_pubertal_status
sexual_maturity_index
menstrual_regularity
time_to_resumption_menses
spontaneous_gonadal_function
premature_ovarian_insufficiency		`ncit:C80099`	A condition in which the ovaries stop working and menstrual periods stop before age 40. Natural menopause usually occurs around age 50. A woman is said to be in menopause when she hasn't had a period for 12 months in a row. Symptoms of menopause include hot flashes, mood swings, night sweats, vaginal dryness, trouble concentrating, and infertility. Premature menopause can be caused by some cancer treatments, surgery to remove the ovaries, and certain diseases or genetic conditions.

Slot Icons:Required

AdverseEvents `0..*`

AdverseEvents captures toxicities, complications, infections, GVHD, adverse-event grading, attribution, interventions, hospitalization, outcomes, and other treatment-related safety events.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_ae	`integer`	`ncit:C172677`	Age of subject (in days) at the onset of the adverse event.
age_at_ae_resolved	`integer`	`ncit:C175043`	Age of subject (in days) at adverse event resolution.
ae_treatment
ae_detection_method		`ncit:C185658`	An evaluation prior to the completion of therapy that the individual is responding rapidly to therapy.
adverse_event		`ncit:C41331`	An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse effects do not have to be caused by the drug or therapy, and they may be mild, moderate, or severe.
ae_site		`ncit:C157120`	The anatomic site of the tumor.
laterality		`ncit:C164550`	A coded value specifying the side of the entity.
ae_code	`string`	`ncit:C173313`	The code of the adverse event.
ae_system		`ncit:C168872`	The name of the system used to grade the adverse events.
ae_system_version	`string`	`ncit:C173314`	The version of the adverse event grading system.
ae_grade		`ncit:C166200`	A numeric value corresponding to the degree of severity of an adverse event.
icu		`ncit:C173316`	An indication of whether the subject was admitted to the intensive care unit.
supportive_medication		`ncit:C173317`	The medication related to the adverse event.
ae_pathogen		`ncit:C185665`	The pathogen identified as the agent causing the adverse event.
ae_pathogen_confirmation		`ncit:C168955`	An indication that the reported pathogen was confirmed or suspected as the cause of an infection.
infection_classification		`ncit:C178091`	The type of evidence regarding the infection type.
gvhd_acuity		`ncit:C168861`	The assessed level of seriousness assigned to the graft versus host disease.
gvhd_organ		`ncit:C168883`	The organs involved in the graft vs host disease.
ae_immune		`ncit:C185661`	An autoimmune-like adverse reaction caused by immunotherapy.
ae_infusion		`ncit:C185663`	An adverse event that can be related to an infusion.
ae_reported		`ncit:C185669`	The adverse event has been reported per protocol.
ae_attribution		`ncit:C41358`	A specific identifiable level (defined qualitatively or quantitatively) of probability of adverse event being caused or associated with the product or procedure administration to a patient.
ae_expected		`ncit:C93710`	Specifies whether the nature, frequency, or severity of an adverse event is consistent with the applicable study documentation (e.g., investigator's brochure, protocol document, or consent document) or product labeling (package insert).
ae_tx_mod		`ncit:C53606`	An indication that a change in treatment or a change to a device will be required following an adverse event.
ae_hospitalization		`ncit:C83052`	An indication or description that an adverse event is associated with or prolongs hospitalization.
ae_medication		`ncit:C173317`	The medication related to the adverse event.
ae_intervention_status		`ncit:C173318`	An intervention was administered to treat the adverse event.
ae_intervention		`ncit:C173319`	The intervention or medication detail of the adverse event.
ae_pathogen_status		`ncit:C168955`	An indication that the reported pathogen was confirmed or suspected as the cause of an infection.
ae_outcome		`ncit:C49489`	A condition or event that is attributed to the adverse event and is the result or conclusion of the adverse event.
hospitalization		`ncit:C83052`	An indication or description that an adverse event is associated with or prolongs hospitalization.
hospitalization_reason
hospitalization_reason_other	`string`
avn_joint		`ncit:C178082`	Death of bone tissue in a joint due to temporary or permanent interruption of blood flow.
avn_joint_laterality		`ncit:C178083`	A finding descriptive of the laterality of the avascular necrosis in the joints.
modification_required		`ncit:C55606`	Asymmetry of nipple areolar complex with slight deviation in nipple projection
tox_delay
tox_high_grade_events	`integer`
tox_dose_reductions	`integer`

Slot Icons:Required

SubsequentMalignantNeoplasm `0..*`

SubsequentMalignantNeoplasm records subsequent malignant neoplasms, including site, type, morphology, topography, coding systems, timing, and radiation-field context where available.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_smn	`integer`	`ncit:C168860`	Age of subject (in days) at the diagnosis of the secondary malignant neoplasm.
smn_site
smn_type
morph_code	`string`
morph_code_text	`string`
morph_code_system
morph_code_system_version	`string`
top_code	`string`
top_code_text	`string`
top_code_system
top_code_system_version	`string`
smn_field		`ncit:C175044`	The location of the second malignant neoplasm related to the prior radiation field.

Slot Icons:Required

LateEffects `0..*`

LateEffects captures late effects and survivorship-related outcomes, including evaluation timing, effect type, detail, severity grade, and CTCAE version.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
age_at_le_eval	`integer`	`ncit:C185670`	Age of subject (in days) when the late effect evaluation was performed.
le		`ncit:C4808`	Any symptom or condition which is a result of a medical intervention but arises months or years after it.
le_detail		`ncit:C185686`	An in-depth explanation of a health problem that occurs months or years after a disease is diagnosed or after treatment has ended.
le_sub_detail		`ncit:C186352`	An added in-depth or explanation of a health problem that occurs months or years after a disease is diagnosed or after treatment has ended.
le_severity_grade		`ncit:C186476`	A severity grade assigned to the late effects.
le_ctcae_version	`string`	`ncit:C185691`	The version of the Common Terminology Criteria for Adverse Events (CTCAE) Terminology.

Slot Icons:Required

PatientReportedOutcomesMetadata `0..*`

PatientReportedOutcomesMetadata describes patient-reported outcome study instruments, measurement types, raters, time points, and eligible age ranges.

Diagram

Slot	Range	Slot URI	Description
pro_study_id	`string`
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
time_point		`ncit:C82576`	The point in time that acts as a fixed reference point to an event.
pro_measures		`ncit:C177377`	Name of the PRO Instrument containing the question - value pair reported. The most consistently recommended system is Priority 1. Other systems may be used. The list specifies the highest priority instruments.
pro_measurement_type		`ncit:C186353`	The type of patient reported outcome measurement.
raters		`ncit:C185700`	Raters are allowed to report the patient reported outcomes.
eligible_age_lower	`integer`	`ncit:C185672`	The low age range of the child for an evaluation tool.
eligible_age_upper	`integer`	`ncit:C185673`	The upper age range of the child for an evaluation tool.

Slot Icons:Required

ReproductiveOutcomes `0..*`

ReproductiveOutcomes captures pregnancy, conception, tissue utilization, fertility treatment, delivery, birth, and menstrual-status outcomes following cancer therapy or fertility preservation.

Diagram

Slot	Range	Slot URI	Description
honest_broker_subject_id	`string`	`ncit:C168949`	Subject identifier assigned by the honest broker.
episode_submitter_id	`string`
age_at_pregnancy	`integer`
gestational_age_end_of_pregnancy_days	`integer`
age_at_pregnancy_method
age_precision		`ncit:C48045`	A quantitative representation of the degree of accuracy necessary for or associated with a particular action.
pregnancy_attempted
pregnancy_achieved
pregnancy_person
fertility_tissue_utilized
tissue_type_utilized
conception_type
oocyte_or_embryo_source
sperm_source
oocyte_or_embryo_state
sperm_state
plurality	`integer`
pregnancy_outcome
delivery_route
birth_order	`integer`
birth_weight	`decimal`
birth_weight_unit

Permissible Value	Meaning	Description
Active
Resolved

Permissible Value	Meaning	Description
All Colonoscopies
Only Screening Colonoscopies
Other
Unknown

Permissible Value	Meaning	Description
Adenoma Only
Adenoma and Sessile Serrated Polyps
Unknown

Permissible Value	Meaning	Description
Eye	`C12401`	An organ that detects light.
Femoral Artery
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Definite	`ncit:C53260`	A characteristic used to qualify the adverse event as certainly related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, occurring in a plausible time relationship to medical intervention, and which cannot be explained by concurrent disease or other interventions. The response to withdrawal of the medical product (dechallenge) should be clinically plausible. The event must be definitive pharmacologically or phenomenologically, using a satisfactory rechallenge procedure if necessary.
Possible	`ncit:C53258`	A characteristic indicating that an adverse event may be related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a reasonable time sequence to administration of the drug, but which could also be explained by concurrent disease or other drugs or chemicals. Information on drug withdrawal may be lacking or unclear.
Probable	`ncit:C41357`	Probable adverse event relationship to study product or procedure is defined when there is a clear-cut temporal association between product or procedure administration and adverse event, and a potential alternative etiology of the event is not apparent.
Unlikely	`ncit:C53257`	A characteristic used to qualify the adverse event as unlikely related to the medical intervention. According to WHO causality assessment criteria of suspected adverse reactions it is applicable to a clinical event, including laboratory test abnormality, with a temporal relationship to the medical intervention which makes a causal relationship improbable, and in which other interventions or underlying disease provide plausible explanations.
Unrelated	`ncit:C53256`	A characteristic used to qualify the adverse event as clearly not related to the medical intervention.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Expected	`ncit:C41333`	Any adverse event associated with a medical product or procedure, whose nature and severity have been previously observed, identified in nature, severity, or frequency, and documented in the investigator brochure, investigational plan, protocol, current consent form, scientific publication, or in other relevant and reliable document. The old term Side Effect is retired and should not be used.
Unexpected	`ncit:C41334`	An adverse reaction, whose nature, severity, specificity, or outcome is not consistent with the term or description used in the applicable product information. [ICH E2] See also adverse drug reaction.

Permissible Value	Meaning	Description
CTCAE >> Grade 1
CTCAE >> Grade 2
CTCAE >> Grade 3
CTCAE >> Grade 4
CTCAE >> Grade 5
RTOG >> Grade 3/Grade 4
RTOG >> Grade1/Grade2
System NOS >> Grade 1	`ncit:C41338`	A type of adverse event that is usually transient and may require only minimal treatment or therapeutic intervention. The event does not generally interfere with usual activities of daily living.
System NOS >> Grade 2	`ncit:C41339`	A type of adverse event that is usually alleviated with additional specific therapeutic intervention. The event interferes with usual activities of daily living, causing discomfort but poses no significant or permanent risk of harm to the research participant.
System NOS >> Grade 3	`ncit:C41340`	A type of adverse event that interrupts usual activities of daily living, or significantly affects clinical status, or may require intensive therapeutic intervention.
System NOS >> Grade 4	`ncit:C41337`	An adverse event, and/or its immediate sequelae, which is associated with an imminent risk of death or which is associated with physical or mental disabilities that affect or limit the ability of a person to perform activities of daily living (eating, ambulation, toileting, etc.) See NCI Common Terminology Criteria for Adverse Events.
System NOS >> Grade 5	`ncit:C48275`	The termination of life as a result of an adverse event. (NCI)
Clavien-Dindo, Grade I	`ncit:C121447`	Any deviation from the normal postoperative course without the need for pharmacological treatment or surgical, endoscopic, and radiological interventions.
Clavien-Dindo, Grade II	`ncit:C121447`	Any deviation from the normal postoperative course without the need for pharmacological treatment or surgical, endoscopic, and radiological interventions.
Clavien-Dindo, Grade III	`ncit:C121449`	A complication requiring surgical, endoscopic, or radiological intervention.
Clavien-Dindo, Grade IIIa	`ncit:C121450`	A complication requiring intervention not under general anesthesia.
Clavien-Dindo, Grade IIIb	`ncit:C121451`	A complication requiring intervention under general anesthesia.
Clavien-Dindo, Grade IV	`ncit:C121452`	A life-threatening complication.
Clavien-Dindo, Grade IVa	`ncit:C121453`	Single organ dysfunction.
Clavien-Dindo, Grade IVb	`ncit:C121454`	Multiorgan dysfunction.
Clavien-Dindo, Grade V	`ncit:C121455`	Death of a patient.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
ACE-Inhibitor	`ncit:C247`	A drug that is used to lower blood pressure. An ACE inhibitor is a type of antihypertensive agent.
Arthroplasty, Hemi/Resurfacing	`ncit:C178086`	The trimming and capping of the joint head with ceramic, metal or plastic components and the removal of damaged bone and cartilage within the socket and replacement with a metal shell.
Arthroplasty, Total	`ncit:C178087`	The removal of the joint head and neck, and replacement with ceramic, metal or plastic components and the removal of damaged bone and cartilage within the socket and replacement with a metal shell.
Bone Graft, Free Vascularized	`ncit:C178088`	Bone grafts that have their own blood supply.
Bone Graft, Nonvascularized	`ncit:C178089`	Bone grafts without a blood supply.
Chondroplasty	`ncit:C178090`	An outpatient procedure to repair damaged cartilage in the knee.
Core Decompression	`ncit:C157826`	A surgical procedure in which areas of dead bone are drilled to increase blood flow, slow or stop tissue destruction and decrease pressure.
Heart Transplant	`ncit:C15246`	A surgical procedure in which a damaged heart is removed and replaced by another heart from a suitable donor.
Inotropic Support	`ncit:C168966`	An agent used to modify the strength of the contraction of the heart muscle.
Osteotomy	`ncit:C51903`	Surgical cutting or removal of bone.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Death, Contributory	`ncit:C168948`	Any adverse event contributing to the cause of death.
Death, Noncontributory	`ncit:C173315`	The adverse event did not directly contribute to the death of the subject.
Not Recovered	`ncit:C49494`	One of the possible results of an adverse event outcome that indicates that the event has not improved or recuperated.
Not Yet Recovered	`ncit:C49494`	One of the possible results of an adverse event outcome that indicates that the event has not improved or recuperated.
Recovered	`ncit:C49498`	One of the possible results of an adverse event outcome that indicates that the event has improved or recuperated.
Recovered with Sequelae	`ncit:C49495`	One of the possible results of an adverse event outcome where the subject recuperated but retained pathological conditions resulting from the prior disease or injury.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Confirmed	`ncit:C25458`	Having been established or verified.
Suspected	`ncit:C71458`	Believed likely.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Bacteria	`ncit:C14187`	A large group of single-cell microorganisms. Some cause infections and disease in animals and humans. The singular of bacteria is bacterium.
Fungus	`ncit:C14209`	A eukaryotic, heterotrophic organism that lives as a saprobe or parasite, and includes yeasts and molds. It reproduces either sexually or asexually, and has a life cycle that ranges from simple to complex.
Virus	`ncit:C14283`	An infectious agent that comprises two parts: genetic material and a protein coat. These organisms lack independent metabolism, and they must infect the cells of other types of organisms to reproduce.
Other	`ncit:C17649`	A proper value is applicable but not known.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Balis Neuropathy Scale	`ncit:C178081`	An instrument used to grade neurotoxicity occurring in children on a 0-4 scale, where the higher number indicates worse neuropathy.
Clavien-Dindo Classification
CTCAE	`ncit:C49704`	A standard terminology developed and maintained by the National Cancer Institute to report adverse events occurring in cancer clinical trials. The CTCAE contains a grading scale for each adverse event term representing the severity of the event. (NCI)
European Society for Blood and Marrow Transplantation (EBMT)	`ncit:C168842`	A non-profit organization established in 1974 to allow scientists and physicians involved in clinical bone marrow transplantations to share experiences and develop co-operative studies.
ICD
RTOG	`ncit:C19778`	A multi-institutional cooperative organization, a national cancer study research group comprised of 250 of the major research institutions nationally and in Canada, funded by NCI, headquartered in Philadelphia with almost 30 years of experience in running clinical trials. More than 40 clinical trials that involve radiation therapy either alone or in conjunction with surgery and/or chemotherapeutic drugs are active at any one time within RTOG. The group is interested in quality of life issues and their effects on the cancer patient
SNOMED
Other	`ncit:C17649`	A proper value is applicable but not known.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Alternative Medications
Chemotherapy
Immunotherapy
Radiation Therapy
Stem Cell Transplant
Unknown
Not Reported

Permissible Value	Meaning	Description
Last Menstrual Period
Day of Implantation
Ultrasound Dating
Unspecified Method
Unknown	`ncit:C17998`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
Approximate	`ncit:C45828`	Not quite exact or correct; almost exact or correct.
Exact	`ncit:C86021`	Marked by strict and particular and complete accordance with fact.

Permissible Value	Meaning	Description
Occasional / Social	`ncit:C126382`	An individual who drinks from time to time, but generally less than once per week.
Heavy	`ncit:C126384`	A man who drinks more than 14 standard drinks per week or a woman who drinks more than 7 standard drinks per week.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Compound Heterozygous	`ncit:C198518`	Having two different allelic forms of a gene, one inherited from each parent, where each allele harbors a different genetic variation or gene mutation.
Hemizygous	`ncit:C64346`	Having only one copy of a particular gene or genetic region.
Heterozygous	`ncit:C45825`	Having two different allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
Homozygous	`ncit:C45826`	Having two identical allelic forms of a gene, one inherited from each parent, on each of the two homologous chromosomes.
Mosaic	`ncit:C88144`	An individual containing two or more populations of genetically different cells that arose from a single zygote.

Permissible Value	Meaning	Description
Negative	`ncit:C38757`	A finding of normality following an examination or investigation looking for the presence of a microorganism, disease, or condition.
Not Done	`ncit:C49484`	Indicates a task, process or examination that has either not been initiated or completed. (NCI)
Positive	`ncit:C35682`	A laboratory test result that indicates that a specific disease, condition, or attribute being assessed is present.

Permissible Value	Meaning	Description
Amplification	`ncit:C16605`	An increase in the number of copies of a gene. There may also be an increase in the RNA and protein made from that gene. Gene amplification is common in cancer cells, and some amplified genes may cause cancer cells to grow or become resistant to anticancer drugs. Genes may also be amplified in the laboratory for research purposes.
Chromothripsis	`ncit:C129355`	A cytogenetic abnormality characterized by the occurrence of a large number of chromosomal rearrangements that are restricted to sites in one or a few chromosomes. Chromothripsis may result from a single catastrophic event that causes multiple double-strand breaks, which are subsequently repaired or reassembled by error-prone DNA repair pathways or through aberrant DNA replication mechanisms.
Copy Neutral Loss of Heterozygosity	`ncit:C18016`	A genetic variation where gain, loss, or exchange of DNA results in monoallelic loss of function mutations in a diploid cell. In the context of tumor suppressor genes, where a single copy is sufficient for functionality, loss of function for the second allele is associated with tumorigenesis.
Frameshift	`ncit:C17354`	A mutation occurring within the protein-coding region of a gene which results in a shift in the reading frame of the encoded protein. Frameshift mutations often result in the premature truncation of a gene product.
Gain	`ncit:C189957`	A finding indicating the detection of more than the normal number of copies of a gene or genetic/genomic segment in a sample.
Gene Fusion	`ncit:C20195`	Any hybrid gene formed from two previously separate genes. Such fusions occur as a result of translocation, intersititial deletion or chromosomal inversion, and often result in gene products with functions different from the two fusion partners. Gene fusions are associated frequently with hematological cancers, sarcomas and prostate cancer.
Inframe	`ncit:C62199`	A mutation occurring within the protein-coding region of a gene which results in a retention of the reading frame of the encoded protein.
Isochromosome	`ncit:C3897`	An abnormal chromosome with identical arms, formed by transverse splitting of the centromere during chromosomal replication.
Loss	`ncit:C189958`	A finding indicating the detection of less than the normal number of copies of a gene or genetic/genomic segment in a sample.
Missense	`ncit:C18133`	A point mutation occurring within the protein-coding region of a gene, and which codes for a different amino acid than expected.
Monosomy	`ncit:C3239`	A chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number.
No Gain/Loss/Amplification
Nonsense	`ncit:C62198`	A mutation that alters the genetic code in a way that causes the premature termination of a protein. The altered protein may be partially or completely inactivated, resulting in a change or loss of protein function.
Nullisomy	`ncit:C198674`	A chromosomal abnormality consisting of the absence of both copies of a pair of homologous chromosomes.
Splice Acceptor	`ncit:C45389`	A heritable single nucleotide polymorphism located at the acceptor splice site in certain allelic variants of eukaryotic genes. These sites are located in genes at intron to exon junctions at the 3' end of the intron.
Splice Donor	`ncit:C45390`	An inherited single base change at a donor splice site in a genomic DNA sequence that results in an allelic variant of the wild-type gene. Donor splice sites are located at exon to intron junctions at the 5' end of the intron.
Start Lost	`ncit:C148649`	A mutation occurring within the start codon of a gene that results in a sequence that no longer encodes a start codon. This can result in a gene deletion or gene transcription may start from an alternative start site.
Stop Gained	`ncit:C62198`	A mutation that alters the genetic code in a way that causes the premature termination of a protein. The altered protein may be partially or completely inactivated, resulting in a change or loss of protein function.
Stop Lost	`ncit:C148650`	A mutation occurring within the stop codon of a gene that results in a sequence that no longer encodes a stop codon and results in the transcription of non-coding regions downstream of the gene.
Synonymous	`ncit:C20629`	A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected.
Trisomy	`ncit:C3421`	A chromosomal abnormality consisting of the presence of one chromosome in addition to the normal diploid number.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
3' UTR	`ncit:C13373`	Sequences on the 3' end of messenger RNAs that are not translated into protein. The 3'UTR is involved in many post-transcriptional regulatory pathways, including regulating translation efficiency, mRNA stability, and polyadenylation signals.
5' UTR	`ncit:C13371`	Sequences on the 5' end of messenger RNAs that are not translated into protein. 5'UTR extends from the transcription start site to just before the ATG translation initiation codon. This region contains the ribosome binding site and other transcription and translation regulating sequences.
Intronic	`ncit:C45387`	Single Nucleotide Polymorphism in Intronic Sequences (Intronic SNP) consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a transcribed non-coding intervening DNA sequence separating protein-coding sequences (exons) in an eukaryotic nuclear gene. Poorly conserved and of variable length and number, intron sequences are removed from nascent message RNA transcripts in the nucleus after the 5' cap and polyA tail have been added. Self-complementary sequences at exon-intron junctions form a hairpin structure recognized by enzymes that splice exons together into a mature mRNA that is ready for translation in the cytoplasm. When the intron is removed, the donor junction at the 5' end of the intron is spliced to the acceptor junction at the 3' end of the intron.
Promoter	`ncit:C13297`	A DNA sequence at which RNA polymerase binds and initiates transcription.
Splice Site	`ncit:C45574`	An inherited single base substitution in a sequence of eukaryotic DNA located in either an acceptor (3' or downstream) or donor (5' or upstream) splice site of a gene. Functional single nucleotide polymorphisms in these intron-exon junctions can cause incorrect RNA splicing which, in turn, alters gene expression.

Permissible Value	Meaning	Description
Deletion	`ncit:C16606`	A deletion that results in the loss of a DNA segment encompassing an entire gene sequence.
Duplication
Indel
Insertion	`so:0000667`	The sequence of one or more nucleotides added between two adjacent nucleotides in the sequence.
Inversion
Rearrangement, NOS
Substitution	`so:1000002`	A sequence alteration where the length of the change in the variant is the same as that of the reference.
Translocation
Unknown
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Ann Arbor A Symptoms Indicator	`ncit:C185483`	An indication of whether a record includes A-symptom data based on the Ann Arbor lymphoma classification system guidelines.
Ann Arbor B Symptoms Indicator	`ncit:C177585`	An indication of whether a record includes B-symptom data based on the Ann Arbor lymphoma classification system guidelines.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Abnormal	`ncit:C168875`	Any abnormality in the number, length, centromere position, banding pattern or differences between the chromosomes that is not representative of a normal set of chromosomes.
Normal	`ncit:C162623`	Tissue sample with cellular composition and architectural patterns expected for the particular anatomic site in which it belongs. There is no evidence of abnormal cellular infiltrates or tumor mass formation.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
cm	`ncit:C49668`	A basic unit of length equal to one hundredth of a meter or approximately 0.393700787 inch.
kg	`ncit:C28252`	A basic SI unit of mass. It is defined as the mass of an international prototype in the form of a platinum-iridium cylinder kept at Sevres in France. A kilogram is equal to 1,000 grams and 2.2046226 pounds.
kg/m2	`ncit:C49671`	A unit expressed as kilogram of mass per square meter of area.(NCI)
m2	`ncit:C42569`	A SI unit of area measurement equal to a square whose sides are one meter long. Square meter is equal to 10,000 square centimeters; 0.01 are; 1.196 square yards; 10.76 square feet; 1550 square inches.
lb
inch
Unknown
Not Reported

Permissible Value	Meaning	Description
BMI	`ncit:C138901`	The result of a body mass index measurement.
BSA	`ncit:C25157`	A measure of the 2-dimensional extent of the body surface (i.e., the skin). Body surface area (BSA) can be calculated by mathematical formula or from a chart that relates height to weight. BSA is often an important factor in dosing.
Head Circumference	`ncit:C81255`	A circumferential measurement of the head at the widest point, which is traditionally above the eyebrows.
Height	`ncit:C164634`	A measurement that describes the vertical measurement or distance from the base, or bottom, of the patient, to the top of the patient; this can be taken as the dimension of extension of a patient who cannot stand.
Weight	`ncit:C81328`	A measurement that describes the vertical force exerted by a mass of the patient as a result of gravity.

PCDC Data Model

Subject 1..1

ExternalReference 0..*

StudyMetadata 1..1

StudySubgroupAssignment 0..*

ClinicalEpisode 0..*

Consult 0..*

OffProtocolTherapyOrStudy 0..*

SurvivalCharacteristics 0..*

FamilyMedicalHistory 0..*

MedicalHistory 0..*

SocialAndBehavioralDeterminantsOfHealth 0..*

ProviderCharacteristics 0..*

VitalsAndAnthropometrics 0..*

LaboratoryTest 0..*

GeneticAnalysis 0..*

Biospecimen 0..*

FunctionTest 0..*

Immunohistochemistry 0..*

Diagnosis 1..*

Staging 0..*

DiseaseSiteAssessment 0..*

DiseaseCharacteristics 0..*

SurgicalProcedures 0..*

Medication 0..*

LocoregionalTherapy 0..*

ProtocolTreatmentModifications 0..*

RadiationTherapy 0..*

StemCellTransplant 0..*

TransfusionMedicineProcedure 0..*

CellularImmunotherapy 0..*

FertilityProcedures 0..*

SubjectResponse 0..*

MinimalResidualDisease 0..*

ReproductiveAndPubertalStatus 0..*

AdverseEvents 0..*

SubsequentMalignantNeoplasm 0..*

LateEffects 0..*

PatientReportedOutcomesMetadata 0..*

ReproductiveOutcomes 0..*

ActiveResolvedEnum

AdenomaDetectionRateDenominatorEnum

AdenomaDetectionRateNumeratorEnum

AdministrationSiteEnum

AdverseEventEnum

AeAttributionEnum

AeDetectionMethodEnum

AeExpectedEnum

AeGradeEnum

AeInterventionEnum

AeOutcomeEnum

AePathogenConfirmationEnum

AePathogenEnum

AePathogenStatusEnum

AeSiteEnum

AeSystemEnum

AeTreatmentEnum

AgeAtPregnancyMethodEnum

AgePrecisionEnum

AlcoholConsumptionEnum

AllelicStateEnum

AltStatusEnum

AlterationEffectEnum

AlterationEnum

AlterationRegionEnum

AlterationTypeEnum

AnaplasiaTypeEnum

AnnArborModAbEnum

AnteriorSegmentExamEnum

AnthropometricMeasurementResultUnitEnum

AnthropometricMeasurementTypeEnum

AssessmentReasonEnum

AssistedConceptionEnum

AssociatedConditionEnum

AttributionEnum

AvnJointEnum

BbpsScoreEnum

BiologicalAnalyteEnum

BirthWeightUnitEnum

BmAnalysisMethodAtResponseEnum

Subject `1..1`

ExternalReference `0..*`

StudyMetadata `1..1`

StudySubgroupAssignment `0..*`

ClinicalEpisode `0..*`

Consult `0..*`

OffProtocolTherapyOrStudy `0..*`

SurvivalCharacteristics `0..*`

FamilyMedicalHistory `0..*`

MedicalHistory `0..*`

SocialAndBehavioralDeterminantsOfHealth `0..*`

ProviderCharacteristics `0..*`

VitalsAndAnthropometrics `0..*`

LaboratoryTest `0..*`

GeneticAnalysis `0..*`

Biospecimen `0..*`

FunctionTest `0..*`

Immunohistochemistry `0..*`

Diagnosis `1..*`

Staging `0..*`

DiseaseSiteAssessment `0..*`

DiseaseCharacteristics `0..*`

SurgicalProcedures `0..*`

Medication `0..*`

LocoregionalTherapy `0..*`

ProtocolTreatmentModifications `0..*`

RadiationTherapy `0..*`

StemCellTransplant `0..*`

TransfusionMedicineProcedure `0..*`

CellularImmunotherapy `0..*`

FertilityProcedures `0..*`

SubjectResponse `0..*`

MinimalResidualDisease `0..*`

ReproductiveAndPubertalStatus `0..*`

AdverseEvents `0..*`

SubsequentMalignantNeoplasm `0..*`

LateEffects `0..*`

PatientReportedOutcomesMetadata `0..*`

ReproductiveOutcomes `0..*`

Permissible Value	Meaning	Description
Surveillance Assessment
Symptomatic Assessment
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
In Vitro Fertilization	`ncit:C16580`	A procedure in which eggs are removed from a woman's ovary and combined with sperm outside the body to form embryos. The embryos are grown in the laboratory for several days and then either placed in a woman's uterus or cryopreserved (frozen) for future use.
Intracytoplasmic Sperm Injection	`ncit:C185482`	Injecting a single sperm into the center of an egg.
Other	`ncit:C17649`	A proper value is applicable but not known.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Ankle (distal tibia, instrinsic ankle bones)	`ncit:C32078`	A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus.
Elbow (distal humerus, proximal radius, proximal ulna)	`ncit:C32497`	A joint involving the humerus, radius and ulna bones.
Heel (calcaneus)	`ncit:C161381`	The rounded back part of the foot below the ankle and behind the arch.
Hip (proximal femur)	`ncit:C32742`	A ball-and-socket joint between the head of the femur and the acetabulum.
Knee (distal femur, proximal tibia)	`ncit:C32898`	A joint connecting the lower part of the femur with the upper part of the tibia. The lower part of the femur and the upper part of the tibia are attached to each other by ligaments. Other structures of the knee joint include the upper part of the fibula, located below and parallel to the tibia, and the patella which moves as the knee bends.
Shoulder (proximal humerus)	`ncit:C25203`	A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle).
Wrist (distal radius, distal ulna, instrinsic wrist bones)	`ncit:C33894`	A joint between the distal end of the radius and the proximal row of carpal bones.
Other	`ncit:C17649`	A proper value is applicable but not known.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Segment Score 0	`ncit:C138207`	Unprepared colon segment with mucosa not seen due to solid stool that cannot be cleared.
Segment Score 1	`ncit:C138208`	Portion of mucosa of the colon segment seen, but other areas of the colon segment not well seen due to staining, residual stool and/or opaque liquid.
Segment Score 2	`ncit:C138209`	Minor amount of residual staining, small fragments of stool and/or opaque liquid, but mucosa of colon segment seen well.
Segment Score 3	`ncit:C138210`	Entire mucosa of colon segment seen well with no residual staining, small fragments of stool or opaque liquid.
Surgically Absent
Unknown	`ncit:C17998`	A proper value is applicable but not known.

Permissible Value	Meaning	Description
DNA	`ncit:C449`	A long linear double-stranded polymer formed from nucleotides attached to a deoxyribose backbone and found in the nucleus of a cell; associated with the transmission of genetic information.
RNA	`ncit:C812`	One of two types of nucleic acid made by cells. Ribonucleic acid contains information that has been copied from DNA (the other type of nucleic acid). Cells make several different forms of ribonucleic acid, and each form has a specific job in the cell. Many forms of ribonucleic acid have functions related to making proteins. Ribonucleic acid is also the genetic material of some viruses instead of DNA. Ribonucleic acid can be made in the laboratory and used in research studies.
cfDNA	`ncit:C128274`	DNA found in blood plasma and other bodily fluids that is not associated with cells.
ctDNA	`ncit:C113243`	A type of cell-free DNA composed of small fragments of tumor DNA that are released by tumor cells into the bloodstream of the host.

Permissible Value	Meaning	Description
Flow Cytometry	`ncit:C16585`	A method of measuring the number of cells in a sample, the percentage of live cells in a sample, and certain characteristics of cells, such as size, shape, and the presence of tumor markers on the cell surface. The cells are stained with a light-sensitive dye, placed in a fluid, and passed in a stream before a laser or other type of light. The measurements are based on how the light-sensitive dye reacts to the light.
Morphology	`ncit:C35867`	A light microscopic finding that describes the cellular characteristics and architectural patterns of cell populations in a tissue sample.
Other	`ncit:C17649`	A proper value is applicable but not known.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
M1 (Less Than 5% blasts)	`ncit:C137698`	A semi-quantitative microscopic finding indicating that 5 percent or less of the nucleated cells in a bone marrow sample are immature mononuclear cells.
M2 (5-25% Blasts)	`ncit:C146709`	A semi-quantitative microscopic finding indicating that between 5 and 25 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells.
M3 (Greater Than 25% Blasts)	`ncit:C140330`	A semi-quantitative microscopic finding indicating that 25 percent or more of the nucleated cells in a bone marrow sample are immature mononuclear cells.

Permissible Value	Meaning	Description
None
Sequential
Simultaneous Integrated	`ncit:C121139`	A modification of intensity modulated radiation therapy that allows for the simultaneous delivery of different dose levels to different target volumes within a single treatment fraction. This can result in better sparing of critical structures, more efficient delivery, shorter treatment duration, and better biologic effectiveness.
Unknown	`ncit:C17998`	A proper value is applicable but not known.
Not Reported	`ncit:C43234`	Not provided or available.

Permissible Value	Meaning	Description
Adequate
Excellent	`ncit:C82488`	Conforming to the highest quality or standard.
Fair	`ncit:C82489`	Having no exceptional quality or ability.
Good	`ncit:C64975`	Valuable or useful or agreeable or pleasing.
Inadequate
Not Documented
Poor	`ncit:C77959`	Of low value or worth.

Permissible Value	Meaning	Description
ARUP
Cincinnati Children's Hospital Medical Center
Dana-Farber Cancer Institute	`ncit:C177330`	An institute founded in 1947 in Boston, Massachusetts, committed to providing treatment for adults and children with cancer, and developing cures with cutting-edge research.
Julius-Maximilians-Universität of Würzburg
Laboratorio de Citogenética, Instituto Nacional de Pediatría, México
OHSU
Quest Diagnostics
Stanford University
The Rockefeller University
University of Chicago
University of Minnesota
Other